13th Conference Resources

The 13th International Conference on Typhoid and Other Invasive Salmonelloses was held in Kigali, Rwanda, on December 5-7, 2023. More than 350 researchers and experts gathered to exchange the latest findings and research on typhoid, paratyphoid and invasive nontyphoidal Salmonella disease.


13th International Conference on Typhoid and Other Invasive Salmonelloses

Press Release

The press release previewed the conference themes and topics of discussion.

Photo Gallery

Photos from all three days of the conference are available here.


Presentations can be viewed individually at the links below.

DECEMBER 5, 2023

Plenary: Global Challenges in the Fight Against Typhoid and Invasive Salmonelloses: The Urgency to Act

Fighting Typhoid: The Importance of Evidence for Effective Prevention and Control Amid Urgency to Act
Anuradha Gupta, Sabin Vaccine Institute

Non-Typhoidal Salmonella Invasive Disease as a Leading Cause of Child Death in Africa —Challenges and Opportunities for Management and Control
Samuel Kariuki, Kenya Medical Research Institute

Data inequity and typhoid conjugate vaccines 
Kathleen M. Neuzil, University of Maryland School of Medicine

Oral Abstract Session: Vaccine Voyage I: Navigating the Advancements in Vaccine Research

Serological Response Using ELISA Anti-Vi-IgG After Single Dose of Typhoid Conjugate Vaccine Against Salmonella Typhi Among Children in Hyderabad, Pakistan
Farah N. Qamar, Aga Khan University

The Validity of Different Study Designs in Estimating the Protection of Typhoid Conjugate Vaccine
Xinxue Liu, Oxford Vaccine Group, Department of Paediatrics, University of Oxford,
and the NIHR Oxford Biomedical Research Centre

Duration of Immunity and Booster Responses in Nepal 
Mila Shakya, Patan Academy of Health Sciences, Patan Hospital

Effectiveness of Typhoid Conjugate Vaccine (TCV): A Systematic Review
Amira Mahboob, World Health Organization Regional Office for the Eastern Mediterranean

Efficacy of Typhoid Conjugate Vaccine Against Culture-Confirmed Salmonella Typhi — A Systematic Review and Meta-Analysis
Rabab Batool, Aga Khan University

Safety of Typhoid Conjugate Vaccine Booster Vaccination in Malawian Children
Osward Nyirenda, Blantyre Malaria Project, Kamuzu University of Health Sciences

Test-Negative Design: An Efficient Method to Assess Typhoid Conjugate Vaccine Effectiveness
Matthew Laurens, University of Maryland School of Medicine

A Phase IV Clinical Study to Evaluate the Immunogenicity and Safety of Typhoid Conjugate Vaccine (Typbar TCVA®) in Elderly Population
Raches Ella, Bharat Biotech International

Symposium: Maximizing Learnings from Clinical Trials and Public Sector Use — the Full Public Health Value of Typhoid Conjugate Vaccines

Longer-Term Efficacy of Typhoid Conjugate Vaccine in Malawi
Priyanka Patel, Malawi Liverpool Wellcome Trust

New findings on Immunogenicity of TCV: Booster Dose in School-Aged Children and 1 Versus 2 Dose Regimens in HIV-Exposed Infants
Osward Nyirenda, Blantyre Malaria Project

Typhoid Fever Surveillance in Urban Dhaka, Bangladesh: Risk Factors and Antimicrobial Resistance Pattern
Farhana Khanam, icddr,b

Impact Assessment of National TCV Introduction in Pakistan
Tahir Yousafzai, Aga Khan University

The Impact of a TCV Mass Campaign on Typhoid Fever Cases and Antimicrobial Use in Harare, Zimbabwe
Ioana Diana Olaru, London School of Hygiene & Tropical Medicine

Impact of TCV on Antimicrobial Usage – Data from Malawi RCT
James E. Meiring, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield

Oral Abstract Session: Comprehensive Exploration of iNTS: From Vaccine Trials to Global Epidemiology

Study Design & Initial Data from Phase 1 RCT to Evaluate the Safety, Reactogenicity & Immunogenicity of a Vaccine Against iNTS & Typhoid Fever in Healthy Adults
Yasir Shitu Isa, GSK Vaccines Institute for Global Health

Age-Specific Incidence and Associated Mortality of Invasive Non-Typhoidal Salmonella in Mozambican Children, 2001 – 2019
Inacio Mandomando, Centro de Investigação em Saúde de Manhiça

Severe Anaemia Increases Risk Of Invasive Non-Typhoidal Salmonella Bacteraemia In Kenyan Children
Kelvin Mokaya Abuga, KEMRI-Wellcome Trust Research Programme

Modelling the Global Prevalence of Antimicrobial Resistant Invasive Non-Typhoidal Salmonella Infections, 2000 to 2019
Frederick Fell, University of Oxford

IgG and IgA Antigen-Specific B Memory Responses in Healthy U.S. Adults Immunized with a Parenteral Trivalent Salmonella Conjugate Vaccine (TSCV)
Marcelo Sztein, University of Maryland School of Medicine

Antimicrobial Resistance and Intestinal Shedding of Non-Typhoidal Salmonella Among Children Under Five Years and Carriage in Asymptomatic Hosts in Kenya
Celestine Wairimu, Kenya Medical Research Institute

Acquisition of Immunity to Non-Typhoidal Salmonella in Malawian Children to Inform Vaccine-Derived Immunity; a Serological Catalytic Model
Helen Dale, University of Liverpool

The Burden of Invasive Non-Typhoidal Salmonella Disease in Six Sites in Africa: Results from the Severe Typhoid Fever Surveillance in Africa Program
Hyonjin Jeon, International Vaccine Institute

DECEMBER 6, 2023

Symposium: Salmonella Controlled Human Infection Models — Insights, Opportunities and Challenges

Preliminary Results From an Oral Vaccine in the Paratyphoid Human Challenge Model
Naina McCann, Oxford Vaccine Group, Department of Paediatrics, University of Oxford

Development of a Non-Typhoidal Salmonella Challenge Model
Christopher Smith, Department of Infectious Disease, Imperial College London

Plenary: Amplifying Impact: Tools and Solutions to Accelerate Progress

Accelerating Impact Through Mindful Management of Innovation
Jerome Kim, International Vaccine Institute

Advances in serology for enteric fever diagnostics and sero-surveillance
Richelle Charles, Massachusetts General Hospital/Harvard University

Integrating Artificial Intelligence to Analyze Typhoid and Other Invasive Salmonelloses Data: From Zero to Hero!
Bráulio Roberto Gonçalves Marinho Couto, Biobyte Sistemas Ltda

Progress and Challenges Towards Typhoid Diagnostics
Jyotshna Sapkota, FIND

Oral Abstract Session: Inside Out: Genomic and Antimicrobial Resistance in Salmonella

Role of Bacteriophage Defense Systems in the Spread of Drug-Resistant Salmonella Typhi
Yogesh Hooda, Child Health Research Foundation

Salmonella Paratyphi B: Genomic analysis and Antimicrobial Resistance across different regions
Junaid Iqbal, Aga Khan University

Assessing the Global Risk of Typhoid Outbreaks Caused by Extensively Drug Resistant Salmonella Typhi
Jo Walker, Yale School of Public Health

Recent Emergence of Cephalosporin Resistant Salmonella Typhi Carrying IncFIB(K) Plasmid Encoding blaCTX-M-15 Gene in India
Tharani Priya Thirumoorthy, Christian Medical College, Vellore

A 24-Year Passive Surveillance Study Reveals Trends in Antimicrobial Resistance Amongst Salmonella Typhi and Paratyphi A Cases in Bangladesh
Arif Mohammad Tanmoy, Child Health Research Foundation

Genetic Heterogeneity in the Salmonella Typhi Vi Capsule Locus: A Population Genomic Study from Fiji
Aneley Getahun Strobel, Peter Doherty Institute for Infection and Immunity, University of Melbourne

The Genetic Landscape of Salmonella Enterica Serovar Typhi in Zimbabwe Before the Introduction of Typhoid Conjugate Vaccine (TCV)
Tapfumanei Mashe, Ministry of Health and Childcare, World Health Organization

Genomic Characterization of Invasive Salmonella Enterica Isolated in Severe Typhoid in Africa Surveillance in Ibadan, Nigeria
Oyeniyi Stephen Bejide, Chrisland University

Oral Abstract Session: Vaccine Voyage II: Navigating the Advancements in Vaccine Research

Vaccines for All: The Malawi National Integrated Typhoid Conjugate Vaccine Campaign
Latif Ndeketa, Malawi Liverpool Wellcome Programme

Antimicrobial Susceptibility Patterns of Salmonella Typhi Isolates Following Mass-Targeted Typhoid
Conjugate Vaccine Immunization in Harare City, Zimbabwe, 2023
Kudzai Patience Takarinda, National Microbiology Reference Laboratory Zimbabwe

Modeling Typhoid Vaccination in Nepal: TCV Impact and Booster Dose Strategy
Virginia Pitzer, Yale University

Trend of anti-Vi-IgG and anti-Vi-IgA Antibody Responses Induced in Vi-TT Recipients Over the Period
of Five Years Among Bangladeshi Children
Farhana Khanam, icddr,b

Assessing the Medium-Term Impact of a Typhoid Conjugate Vaccine in Preventing Typhoid Infections in Bangladesh
Firdausi Qadri, icddr,b

The Association Between Vaccine Coverage and Herd Protection: Exploratory Analyses of a Cluster-Randomised Trial of Vi Conjugate Vaccine
Yiyuan Zhang, Oxford Vaccine Group and National Institute for Health and Care Research Oxford Biomedical Research Centre

Durability of Anti-Vi IgG and IgA Responses in 15-month-old Children Vaccinated with a Typhoid
Conjugate Vaccine in Burkina Faso
Alphonse Ouedraogo, Groupe de Recherche Action en Santé

Introduction of Typhoid Conjugate Vaccine – A Successful Implementation in Strengthening National Immunization Program of Nepal
Navneet Bichha, Indian Institute of Health Management Research

Symposium: Bridging the Gap: Environmental and Sero-Surveillance for Estimating Typhoid Burden and Supporting Vaccine Introduction

Latest Advances in Seroepidemiology for Enteric Fever
Kristen Aiemjoy, University of California Davis & Mahidol University Faculty of Tropical Medicine

Quick and Informative: Schools as a Platform for Rapid Typhoid Seroepidemiological Assessments
Shiva Naga, Dhulikhel Hospital, Kathmandu University and Sira Jam Munira, Child Health Research Foundation

Mapping Typhoid Transmission: Geospatial Analysis and Seroepidemiology for TCV Prioritization
Momin Kazi, Aga Khan University

A Target Product Profile for Wastewater Surveillance of S. Typhi
Supriya Kumar, Bill & Melinda Gates Foundation

Seroincidence of Enteric Fever based on Targeted Serosurveillance in Blantyre, Malawi
Jonathan Mandolo, Liverpool School of Tropical Medicine

Wastewater Surveillance of S. Typhi in India and Comparison with Clinical and Serological Surveillance
Dilip Abraham, Christian Medical College, Vellore

Direct Sequencing of S. Typhi in Wastewater Samples to Determine Antimicrobial Resistance and Genotype
Catherine Troman, Imperial College London

Oral Abstract Session: Eyes on Surveillance: Illuminating the Path to Effective Monitoring

Development of a Low-Cost Environmental Surveillance Method for Effective Typhoid Fever Control
Shuborno Islam, Child Health Research Foundation

Leveraging Paired Serology to Estimate the Incidence of Typhoidal Salmonella Infection in the STRATAA Study
Jo Walker, Yale School of Public Health

Estimating the Burden of Environmental Salmonella Typhi in the Asante Akim North District of Ghana: The Role of Novel Techniques
Michael O. Owusu, Kwame Nkrumah University of Science and Technology

The Burden and Trend of Typhoid Fever in Low- and Middle-Income Countries: An Updated Meta-Regression Approach
Harsh Vivek Harkare, Swiss Tropical and Public Health Institute and University of Basel

Blood Culture Positive Typhoid and Paratyphoid Cases in Children Presenting to Patan Hospital, Nepal, Over a 14-Year Period (2009-2022)
Shrijana Shrestha, Patan Academy of Health Sciences

The Ty-FIVE Project — Strengthening Typhoid Surveillance Around a Mass Vaccination Campaign in the Northern Division of Fiji
Alumita Vuakanisakea, Ty-FIVE Project, International Vaccine Institute

Typhoid-Associated Ileal Perforations Following the Introduction of the Typhoid Conjugate Vaccine in Pakistan: Findings from a Multi-Center Surveillance Study
Saqib Hamid Qazi, Aga Khan University

Molecular Surveillance of Non-Typhoidal Salmonella from Environmental Sources in Disease Endemic Informal Settlement in Nairobi, Kenya
Michael Muraya Mugo, Kenya Medical Research Institute

DECEMBER 7, 2023

Symposium: How Data Drive Decision-Making: Reflections from TCV Introductions in Pakistan and Malawi and the Role of Data Moving Forward

Reflections from TCV Introductions in Pakistan and Malawi and the Role of Data Moving Forward
Emmanuel Mugisha, TyVAC/PATH

Optimizing Surveillance and Interventions to Advance National XDR Typhoid Control: The Pakistan Experience
Nada Taqi, World Health Organization

From Decision-Making to Introduction: How Persistence, Partnership, and Planning Led to the Introduction of Typhoid Conjugate Vaccine in Malawi
Esau Mkisi, PATH

The MENA Typhoid Project: New Insights on Typhoid Burden and Antibiotic Resistance
Kristen Heitzinger, U.S. Centers for Disease Control and Prevention

Symposium: Landscape, Strategy, and Progress Update for iNTS Vaccines in Clinical Development

Prevalence and Distribution of Non-Typhoidal Salmonella enterica Serogroups and Serovars Isolated from Normally Sterile Sites: A Global Systematic Review
John Crump, University of Otago

Sero-Epidemiology of iNTS in Large Field Cohorts from Malawi, Burkina Faso, Kenya and Ghana
Helen Dale, University of Liverpool

Economic Burden of iNTS and Cost-Effectiveness Analysis for a Hypothetical iNTS Vaccine
in Ghana, Burkina Faso and Malawi
Jung-Seok Lee, International Vaccine Institute

The Public Health Need for iNTS Vaccines, and Preferred Vaccine Characteristics
Adwoa Bentsi-Enchill, World Health Organization

A LMIC Perspective on iNTS Vaccine Strategy, and Lessons from Recent Vaccine Introductions
Mike Chisema, Malawi Ministry of Health

Current Status of the Clinical Development of Trivalent Salmonella Conjugate Vaccine (TSCV)
Wilbur Chen, Center for Vaccine Development, University of Maryland School of Medicine

Development of iNTS Conjugate and Preclinical Study for a Novel Trivalent iNTS/Typhoid Vaccine
SoJung An, International Vaccine Institute

Development of GMMA-Based Vaccines Against iNTS: Current Status
Rocio Canals Alvarez, GSK Vaccines Institutes for Global Health

Oral Abstract Session: Mosaic of Insights: An Exploration of Diverse Salmonelloses Topics

Impact of COVID-19 Pandemic on Enteric Fever Diagnosis in Nepal: Findings From the Surveillance of Enteric Fever Asia Project Study
Dipesh Tamrakar, Dhulikel Hospital-Kathmandu University Hospital

The Application of Machine Learning with High-Content Imaging to Infer Antimicrobial Resistance Phenotypes in Salmonella Typhimurium
Sushmita Sridhar, Universidad Peruana Cayetano Heredia and University of New Mexico

Evaluation of a Point-of-Care Multiplex Immunochromatographic Assay (DPP Typhoid Assay)
for the Diagnosis of Typhoid
Zahida Azizullah, Aga Khan University

Design and Initial Data from a Phase 1 RCT to Evaluate the Safety and Immunogenicity of a Vaccine Against S. Typhi and S. Paratyphi A in Healthy European Adults
Usman Nasir Nakakana, GSK Vaccines Institute for Global Health

From Rarity to Clarity: The Potential of Seroepidemiology for Monitoring Typhoid Vaccine Impact
Kristen Aiemjoy, University of California Davis & Mahidol University Faculty of Tropical Medicine

Role of Gallstones in Salmonella Typhi Stool Carriage and Shedding in an Urban Typhoid Endemic Setting in Nairobi, Kenya
Peter Muturi, Kenya Medical Research Institute

The Impact of Surgical Interventions for Severe Typhoid on Families and Healthcare Systems in Rural South Central Niger
Yakoubou Sanoussi, Hopital de la SIM Galmi, Niger

Safety and Immunogenicity of a Bivalent Paratyphoid A-Typhoid Conjugate Vaccine: Phase I Study
Anirudha Potey and Lizzy Jones, University of Oxford

Oral Abstract Session: The Late-Breakers: Unveiling the Latest in Enteric Fever and iNTS Research

Assessing the Protective Efficacy of an Intranasal Vaccine Candidate, rCTB-T2544, Against Typhoid and Paratyphoid Infection Using Iron Overloaded Murine Model
Suparna Chakraborty, ICMR National Institute of Cholera and Enteric Diseases

Diversity and Antimicrobial Resistance of Salmonella Paratyphi A: A Collaborative Global Typhoid Genomics Consortium Initiative
Zoe Anne Dyson, London School of Hygiene & Tropical Medicine

Pan-genome clustering Reveals the Role of Prophage Elements in the Evolution and Adaptation of Salmonella Enteritidis
Jobin John Jacob, Christian Medical College, Vellore

Initial Immunogenicity and Safety Data From a First-in-Human Randomised Controlled Trial of an Invasive Non-Typhoidal Salmonella GMMA Vaccine: the SALVO Trial
Peter D. Skidmore, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, Department of Paediatrics, University of Oxford

Forecasting iNTS for the Global Burden of Disease Study
Jeffrey Stanaway, The Institute for Health Metrics and Evaluation, University of Washington

Unmasking Typhoid Vaccine Hesitancy: A Study of Myths Surrounding TCV in Immunisation Programs Within Refugee Communities in Southwestern Uganda
Muhumuza Umar, Africa Centers for Disease Control

Bacterial Profile of Suspected Typhoid Intestinal Perforation Cases, Regional Hospital Centre, Maradi, Niger
Maman Laminou Sani, Regional Hospital Centre, Maradi

Impact of TCV Introduction on Ileal Perforations in Pakistan: A Comparative Analysis
Huma Syed Hussain, Aga Khan University

Plenary: Forging a Path Forward: The Roadmap to Expand Solutions and Catalyze Change

Charting a Comprehensive and Innovative Path to Fight Typhoid and Invasive Salmonelloses: The Importance of Multi-Sectorial Collaboration, Resource Mobilization, Health Systems Strengthening and Political Will
Robert Agyarko, African Risk Capacity

From Data to Action: Leveraging Existing Primary Healthcare Systems for Solutions
Samba Sow, Center for Vaccine Development-Mali

Accelerating the Fight Against Invasive Salmonella Diseases: Perspectives From WHO
Adwoa Bentsi-Enchill, World Health Organization

Looking Ahead — What Do We Need for Successful Enteric Fever Control?
Duncan Steele, Bill & Melinda Gates Foundation