10th Conference Resources

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The 10th International Conference on Typhoid and Other Invasive Salmonelloses was held in Kampala, Uganda, on April 4-6, 2017. More than 300 researchers and experts gathered to exchange the latest findings and research on typhoid, paratyphoid and invasive nontyphoidal Salmonella disease. The presentations have been gathered here as a resource. Please note that some of the presentations have been excluded at the request of the presenter.

Program

10th International Conference on Typhoid and Other Invasive Salmonelloses

Presentations

April 4

Looking to the Future: Control of Typhoid in the Next Decade

Anita Zaidi, Bill & Melinda Gates Foundation

Progress in Typhoid Fever Epidemiology

John Crump, University of Otago

Incidence, Presentation and Outcomes of Salmonella Bacteraemia Among Young Children in Sub-Saharan Africa: MAL055 RTS,S-AS01 Salmonella Ancillary Study

Cal MacLennan on behalf of the MAL055 RTS,S-AS01 Salmonella Ancillary Study

Enteric Fever Among Outbreaks in Africa: Same Old Foe but Emerging New Challenges in Management

Sam Kariuki, Kenya Medical Research Institute

Clades of Salmonella Associated with Epidemics of Invasive Salmonella Disease

Nick Feasey, Liverpool School of Tropical Medicine

Evaluation of a New Real-Time PCR to Identify S. Typhi, S. Paratyphi A and S. spp. from Patients with Fever in Bangladesh

Stephane Pouzol, Fondation Mérieux

Identification of a New Serodiagnostic Signature of Acute Typhoid Fever Using Salmonella Proteome Arrays

Thomas Darton, University of Oxford

Antigen Discovery for Improved Diagnosis of Invasive Salmonellosis by Targeted Proteomics

Sara Saleh, Institute of Tropical Medicine, Antwerp

Carriage of Salmonella Typhi Among Vendors in Two Kampala Markets

Mark Bumano, Makerere University College of Health Sciences

Typhoid Outbreak Caused by Drinks Made from Contaminated Underground Water Sources in Kampala, Uganda, January-March, 2015

Steven Ndugwa Kabwama, Uganda Public Health Fellowship Program

Salmonella Typhi Bloodstream Infections Among Infants and Children, Korogwe District Hospital, Tanzania

John Lusingu, National Institute for Medical Research

Typhoid Fever in Santiago, Chile: Modern Insights Where Historical Data Meet Mathematical Modeling

Jillian Gauld, Institute for Disease Modeling

Salmonella Typhi Bactericidal Antibody Activity is a Correlate of Disease Severity, but Not Protection Against Typhoid Fever

Andrew Pollard, University of Oxford

Creating a Sustainable Vaccine Landscape: Overcoming Barriers to Vaccine Development and Speed to Market

Vinita Vishwanarayan, Clinton Health Access Initiative

Comparison of Strategies and Thresholds for the Vi Conjugate Vaccine Against Typhoid Fever: A Cost-Effectiveness Modeling Study

Nathan Lo, Stanford University

Development of New Generation Monovalent Typhoid Conjugate Vaccine: Vi-CRM197

Akshay Goel, Biological E

Live Oral Typhoid Vaccine Ty21a Elicited Cross-Reactive Multifunctional IL-17A Producing T Cell Responses Against Salmonella enterica Serovars In Humans

Rezwanul Wahid, University of Maryland School of Medicine

Exploring S. Typhi-Specific HLA-E-Restricted Immune Responses in Pediatric and Adult Ty21a Recipients Using Mass Cytometry

Mark Rudolph, University of Maryland School of Medicine

Whole Genome Sequence Analysis of Salmonella Typhi Isolated in Thailand Before and After the Introduction of a National Immunisation Program

Zoe Dyson, University of Melbourne

Epidemiology and Disease Burden of Typhoid Fever and iNTS Disease in Sub-Saharan Africa

Florian Marks, International Vaccine Institute

The Severe Typhoid Fever Surveillance in Africa (SETA) Program: An Overview

Justin Im, International Vaccine Institute

SETA: The First Data from the Six African Sites

Se Eun Park, International Vaccine Institute

African Risk Factor Prediction Model and Implications for Vaccination Strategies

Jong-Hoon Kim, International Vaccine Institute

At a Glance: The Surveillance for Enteric Fever in Asia Project (SEAP)

Denise Garrett, Coalition against Typhoid, Sabin Vaccine Institute

Approaches to Community Surveys for Typhoid Burden Estimation: Experience from SEAP

Alexander Yu, Stanford University

Salmonella Typhi and Paratyphi in Bangladesh and Their Antimicrobial Resistance

Samir Saha, Child Health Research Foundation

Looking Back While Moving Forward with Enteric Fever Surveillance in Pakistan

Farah Qamar, Aga Khan University

A Retrospective Review of Existing Hospital-Based Data on Enteric Fever in India

Dipika Sur, Translational Health Science and Technology Institute

 

April 5

Development and Challenges in Developing a Sensitive Diagnostic Test for Typhoid Fever

Firdausi Qadri, International Centre for Diarrhoeal Disease and Research, Bangladesh

Vaccine and non-Vaccine Measures for Prevention and Control of Typhoid Fever

Eric Mintz, Centers for Disease Control and Prevention

Gaps in Knowledge in Therapeutics and Treatment

Chris Parry, Liverpool School of Tropical Medicine

The SaniPath Approach to Fecal Exposure Assessment and Application to Typhoid Transmission

Christine Moe, Emory University

A Broad-Spectrum Vaccine to Prevent Invasive Salmonella Disease in Sub-Saharan Africa

Myron Levine, University of Maryland School of Medicine

Antibiogram Pattern, Mechanism of Fluoroquinolone Resistance and Seasonality of Salmonella Serotypes in a North Indian Tertiary Care Hospital

Rajni Gaind, Vardhman Mahavir Medical College & Safdarjung Hospital

The Impact of Antimicrobial Treatment on Pathogen Behavior at the Subpopulation Level During Invasive Salmonella Infections

Pietro Mastroeni, University of Cambridge

Changing Trends in Antibiograms of Salmonella enterica in Pediatric Population — A Hospital Based Study

Bhaskar Shenoy, Manipal Hospital, Bangalore, India

Health Outcomes from Multidrug-Resistant Salmonella in High-Income Countries: A Systematic Review

Andrea Parisi, The Australian National University

Multidrug Resistant Non-Typhoidal Salmonella Hotspots as Targets for Vaccine Use in Management

Sam Kariuki, Kenya Medical Research Institute

Whole Genome Sequencing for Identification, Drug Resistance, Detection and Epidemiology of Salmonella: A Revolution in Public Health Microbiology

Satheesh Nair, Public Health England

Emergence of a New Salmonella Typhimurium ST313 Lineage in D.R. Congo with Increased Antibiotic Resistance and Indications for Further Host Adaptation

Sandra Van Puyvelde, Institute of Tropical Medicine Antwerp

Antimicrobial Pre-Treatment and Blood Culture Positivity Rates for S. Typhi, iNTS and Other Invasive Bacterial Pathogens

Ondari D. Mogeni, International Vaccine Institute

Pre-clinical Immunogenicity of Typhoid (Vi-CRM197), Paratyphoid (O:2- CRM197) and Bivalent (Vi-CRM197+O:2- CRM197) Conjugate Vaccine

Ravi P.N. Mishra, Biological E

Development of a Sustainable and Effective Vaccine Against Invasive Non-Typhoidal Salmonellosis (iNTS) in Africa

Gianluca Breghi, Fondazione Achille Sclavo

Development of a Vaccine Based on GMMA Against Invasive Non-Typhoidal Salmonella Disease in Sub-Saharan Africa

Oliver Koeberling, GSK Vaccines Institute for Global Health

S. Typhimurium Core-OPS (COPS) Glycoconjugate with the Homologous Serovar Phase 1 Flagellin as a Vaccine to Prevent Invasive S. Typhimurium Infections in Sub-Saharan Africa

Raphael Simon, University of Maryland School of Medicine

Measurement of LPS Specific IgA and IgG Avidity Maturation in Vivotif Vaccinees and Naturally Infected Typhoid Patients in Bangladesh

Farhana Khanam, International Centre for Diarrhoeal Disease and Research, Bangladesh

Forecasting Typhoid Conjugate Vaccine Introduction and Demand in Typhoid-Endemic Low and Middle-Income Countries

Enusa Ramani, International Vaccine Institute

Salmonella Challenge Studies: Introduction and Historical Perspective

Andrew Pollard, University of Oxford

Assessment of the Efficacy of a Vi-Tetanus Toxoid Conjugate Vaccine Using a Controlled Human Infection Model of Salmonella Typhi

Celina Jin, University of Oxford

Investigating Immunity to Typhoid and Paratyphoid Fever — The Response to Re-Challenge in a Controlled Human Infection Model

Malick Gibani, University of Oxford

Identifying Correlates of Protection — Systemic Immune Responses to Salmonella Typhi and Paratyphi A Infection

Giorgio Napolitani, University of Oxford

Mucosal Immune Responses to Salmonella Typhi and Paratyphi A Infection

Lorena Preciado-Llanes, University of Oxford

Comparative Analysis of Molecular Immune Profiles and Disease Pathogenesis in Typhoid and Paratyphoid Fever

Christoph Blohmke, University of Oxford & Jennifer Hill, University of Oxford

Recent Advances in the Identification of Immunological Correlates of Protection in a Human S. Typhi Challenge Model

Marcelo Sztein, University of Maryland School of Medicine

Towards Human Challenge with NTS

Cal MacLennan, University of Oxford

 

April 6

Overview on Vaccine Pipeline: Current Status and Future Plans

Sushant Sahastrabuddhe, International Vaccine Institute

Introduction of Typhoid Conjugate Vaccines: Opportunities and Challenges

Kathy Neuzil, University of Maryland School of Medicine

Development of a Bivalent Salmonella Typhi and Paratyphi A MAPS Vaccine

Rick Malley, Boston Children’s Hospital/Harvard Medical School

Cost-Effectiveness of Typhoid Conjugate Vaccine Strategies Across Five Settings in Africa and Asia

Virginia Pitzer, Yale School of Public Health

TYPBAR-TCV: A Clinical Development Review

Krishna Mohan, Bharat Biotech

Short Overview and Provenance of the Study

Zulfiqar Bhutta, Aga Khan University

Global Review and Epidemiology

Daina Als, SickKids Centre for Global Child Health

Additional Trend Data from Global Burden of Disease Study

Jeff Stanaway, Institute for Health Metrics and Evaluation

Country Case Study: Chile

Catterina Ferreccio, Escuela de Medicina Pontificia Universidad Católica de Chile

Country Case Study: Pakistan

Jai K. Das, Aga Khan University

Country Case Study: Thailand

Amruta Radhakrishnan, The Hospital for Sick Children

Country Case Study: Nigeria

Kabiru Olusegun Akinyemi, Lagos State University

Virulence of Invasive Salmonella Typhimurium ST313 in Animal Infection Models

Ellen Higginson, University of Maryland School of Medicine

Average Treatment Cost for Typhoid Fever and Average Vaccine Delivery Cost per Dose for Each of the 54 GAVI-Eligible Countries

Joke Bilcke, University of Antwerp

Outbreak Investigation and Assessment of Risk Factors of Ceftriaxone Resistant S. Typhi from Hyderabad, Pakistan

Tahir Yousufzai, Aga Khan University

Salmonella enterica Serovars Isolated from Stool of Children Enrolled in the Global Enteric Multicenter Study in Africa

Irene Kasumba, University of Maryland School of Medicine

Leveraging the WHO-Coordinated IB-VPD Surveillance Platform for Enteric Fever Surveillance: Lessons from Bangladesh

Senjuti Saha, Child Health Research Foundation

A Case-Control Investigation into the Household Distribution of Invasive Salmonellae in Blantyre, Malawi

Melita Gordon, University of Liverpool

Knowledge, Attitudes and Practices Related to Typhoid Fever: The Case of Glen View Suburb, City of Harare, 2016

Kudzai Masunda, City of Harare Health Department

Spatial and Temporal Patterns of Typhoid and Paratyphoid Fever Outbreaks: A Worldwide Systematic Review, 1990-2016

Vittal Mogasale, International Vaccine Institute

Global Typhoid Control in the Context of the Sustainable Development Goals: Pragmatism or Utopia?

Zulfiqar Bhutta, Aga Khan University

Considerations for Revised Global Typhoid Vaccination Policy and Strategies

Adwoa Bentsi-Enchill, World Health Organization

Breaking Good: Making Science Great Again

Robert Breiman, Emory University

Closing Remarks

Bruce Gellin, Sabin Vaccine Institute

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