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Characterization of Salmonella Gallinarum isolates from backyard poultry by polymerase chain reaction detection of invasion (invA) and Salmonella plasmid virulence (spvC) genes

by admin August 30, 2017
AUTHORS Pal S, Dey S, Batabyal K, Banerjee A, Joardar SN, Samanta I, Isore DP ABSTRACT AIM: The aim was to characterize Salmonella enterica serovar Gallinarum isolated from backyard poultry by polymerase chain reaction (PCR) detection of virulence genes invasion (invA) and Salmonella plasmid virulence C (spvC). MATERIALS AND METHODS: Two strains of Salmonella serovar Gallinarum isolates used [...] readmore

Salmonella Typhi genomics: envisaging the future of typhoid eradication

by admin August 23, 2017
AUTHORS Yap KP, Thong KL ABSTRACT Next-generation whole-genome sequencing has revolutionised the study of infectious diseases in recent years. The availability of genome sequences and its understanding have transformed the field of molecular microbiology, epidemiology, infection treatments and vaccine developments. We review the key findings of the publicly accessible genomes of Salmonella [...] readmore

In silico identification and characterization of stress and virulence associated repeats in Salmonella

by admin August 23, 2017
AUTHORS Das G, Das S, Dutta S, Ghosh I ABSTRACT So much genomic similarities yet causing different diseases, is like a paradox in Salmonella biology. Repeat is one of the probes that can explain such differences. Here, a comparative genomics approach is followed to identify and characterize repeats that might play role in adaptation and pathogenesis. Repeats are non-randomly distributed in [...] readmore

Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol

by admin August 23, 2017
AUTHORS Alvarez MI, Glover LC, Luo P, Wang L, Theusch E, Oehlers SH, Walton EM, Tram TTB, Kuang YL, Rotter JI, McClean CM, Chinh NT, Medina MW, Tobin DM, Dunstan SJ, Ko DC ABSTRACT Risk, severity, and outcome of infection depend on the interplay of pathogen virulence and host susceptibility. Systematic identification of genetic susceptibility to infection is being undertaken through [...] readmore

Prevalence and trends in the antimicrobial susceptibility pattern of Salmonella enterica serovars Typhi and Paratyphi A among children in a pediatric tertiary care hospital in South India over a period of ten years: a retrospective study

by admin August 16, 2017
AUTHORS Iyer RN, Jangam RR, Jacinth A, Venkatalakshmi A, Nahdi FB ABSTRACT The aim of this study was to determine the prevalence and trends in the antimicrobial resistance of typhoidal salmonellae in children and adolescents at a pediatric tertiary care hospital in South India. Typhoidal salmonellae were isolated from 483 of the 77,713 blood cultures received during the ten-year study period [...] readmore

Construction of an inactivated typhoid vaccine candidate expressing Escherichia coli heat-labile enterotoxin B subunit and evaluation of its immunogenicity in a murine model

by admin August 16, 2017
AUTHORS Kim B, Won G, Lee JH ABSTRACT PURPOSE: Typhoid fever caused by Salmonella enterica serovar Typhi has contributed to the global public health burden, particularly in developing countries. In this study, an S. Typhi ghost was developed and its capacity as a vaccine candidate against typhoid fever was assessed. METHODOLOGY: An asd+ plasmid pJHL187 harbouring a ghost cassette comprising [...] readmore

The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26–27 October 2016, Oxford, UK

by admin August 15, 2017
AUTHORS James E. Meiring, Malick Gibani, the TyVAC Consortium Meeting Group ABSTRACT Typhoid fever is estimated to cause between 11.9–26.9 million infections globally each year with 129,000–216,510 deaths. Access to improved water sources have reduced disease incidence in parts of the world but the use of efficacious vaccines is seen as an important public health tool for countries with a [...] readmore

Preparedness of adolescents departing from Athens International Airport to Africa or Asia: A five-year airport-based prospective study

by admin August 9, 2017
AUTHORS Maltezou HC, Pavli A, Theodoridou K, Bournousouzis E, Minitsios A, Katerelos P, Lymperi I, Theodoridou M ABSTRACT BACKGROUND: The number of adolescents who travel has increased. We estimated the preparedness of adolescents (12-18 years) departing from Athens to Africa and Asia. METHODS: An airport-based survey was conducted from 2011 to 2015. RESULTS: Sixty-eight adolescents [...] readmore

The global burden of disease study 2013: What does it mean for the NTDs?

by admin August 9, 2017
AUTHORS Jennifer R. Herricks, Peter J. Hotez, Valentine Wanga, Luc E. Coffeng, Juanita A. Haagsma, María-Gloria Basáñez, Geoffrey Buckle, Christine M. Budke, Hélène Carabin, Eric M. Fèvre, Thomas Fürst, Yara A. Halasa, Charles H. King, Michele E. Murdoch, Kapa D. Ramaiah, Donald S. Shepard, Wilma A. Stolk, Eduardo A. Undurraga, Jeffrey D. Stanaway, Mohsen Naghavi, Christopher J. L. Murray [...] readmore

Aga Khan University Team Investigates Outbreak Of Antibiotic Resistant Typhoid Fever In Hyderabad

by admin August 4, 2017
Aga Khan University Team Investigates Outbreak Of Antibiotic Resistant Typhoid Fever In Hyderabad
  Investigators from the Aga Khan University (AKU) are actively investigating a large outbreak of typhoid fever bacteria that are resistant to ceftriaxone, an antibiotic commonly used by physicians to treat this infection. Previous work from investigators at AKU had uncovered very few cases of drug-resistant typhoid, but a recent increase in cases from Hyderabad has alarmed both [...] readmore