Knowledge Exchange Newsletter, November 2016

Stories of Typhoid: Meet Nurunnahar

Meet Nurunnahar. Like many grade-schoolers around the world, this Bangladeshi nine-year-old girl thought she would cool off from the heat of the summer with a glass of lemonade. But this drink, purchased from a street vendor, came with serious consequences.

Within a week, Nurunnahar would develop a fever that rapidly reached a temperature of 104 degrees Fahrenheit. Day by day, she became weaker and the aches and cramps that plagued her grew more painful. By the time her parents checked her in to the hospital, Nurunnahar had lost her appetite and could hardly swallow food or drink. It had been a week since she had become sick. It would be another week before she could return home after being diagnosed with typhoid. Read more about her story.

Typhoid News

There’s a new page on the Coalition against Typhoid website where you can keep track of typhoid news from throughout the year. An easy-to-use menu lets you quickly find news stories from any month in 2016. Take a look! 

Outbreak Watch

  • Haiti – Aid organization Community2Community wants to tackle the lack of infrastructure that is the root cause of cholera and typhoid outbreaks after Hurricane Matthew
  • India – Higher rates of typhoid fever reported in Bengaluru, likely due to over-reliance on water tankers. Coronation Hospital has been running out of typhoid testing kits
  • Kenya – Residents of Kilifi County complain of increasing cases of diarrhea and typhoid as a prolonged drought forces them to drink contaminated water
  • Nepal – Surge in cases of typhoid in Bhojpur, Nepal after patients ate street food at festivals
  • Zimbabwe – An official alert has been issued for cholera and typhoid following 60 reported cases of typhoid in the capital, Harare, and various outbreaks in smaller municipalities. It has been called a “national health crisis“. Four typhoid patients have been admitted to a hospital in the city of Masvingo

From the Blog

Highlighting Typhoid at ASTMH. The Coalition against Typhoid kept typhoid and other invasive salmonelloses on the agenda at the American Society of Tropical Medicine and Hygiene annual meeting, participating in a symposium and hosting a reception with remarks from the top experts in the field.



Genomics and Host Susceptibility

  • Disseminated infections with antibiotic-resistant non-typhoidal Salmonella strains: contributions of host and pathogen factors – Pathogens and Disease
  • Typhoid fever in South Africa in an endemic HIV setting – PLoS One
  • Receptor-Mediated Sorting of Typhoid Toxin During Its Export from Salmonella Typhi-Infected Cells – Cell Host & Microbe


  • The tolerability of a combined hepatitis A and typhoid vaccine in children aged 2-16 years: an observational study – Journal of Travel Medicine
  • Purification of Salmonella Typhimurium OmpD porin induces long-term high levels of antibodies: implications on the development of vaccines against non-typhoid salmonella – Gaceta medica de Mexico
  • Refusal of recommended travel-related vaccines among U.S. international travellers in Global TravEpiNet – Journal of Travel Medicine
  • Development of a live attenuated bivalent oral vaccine against Shigella sonnei shigollosis and typhoid fever – Journal of Infectious Diseases
  • Vi capsular polysaccharide: Synthesis, virulence and application – Critical Reviews in Microbiology


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