Knowledge Exchange Newsletter, April 2017

A Successful Conference

Thank you to all those who presented or attended the 10th International Conference on Typhoid and Other Invasive Salmonelloses in Kampala, Uganda! The three day conference was well-received, convening a diverse audience of 300 individuals from 45 countries. For those who missed it, or would like to share the experience with colleagues, we have the following resources available on our website:

Please feel free to share these widely with your networks, and stay tuned for more information about upcoming typhoid conferences!

New Resource: Career Opportunities

As part of our expanding efforts of serve the typhoid community, the Coalition against Typhoid is adding a career resource to the monthly newsletter to help connect typhoid researchers and advocates to opportunities:

  • The University of Otago Centre for International Health is hiring for a postdoctoral fellow. This position would be primarily responsible for conducting systematic reviews and meta-analyses of published data, landscape analyses of unpublished ongoing work and data gaps analyses on global typhoid fever epidemiology relevant for typhoid vaccine policy. Apply here

From the Blog

Outbreak Watch

  • New Zealand – In Auckland, New Zealand, an imported outbreak of typhoid has killed one person and infected 20 others, some of them asymptomatic. The handling of the outbreak by the public health service has been heavily criticized
  • Philippines – After recording 364 suspected cases of typhoid since January 2017, health officials in the Philippines are reminding the public to be careful of foodborne diseases
  • Tonga – An outbreak of typhoid has pushed officials in Tonga to restrict eating and drinking in public places for a month
  • Zimbabwe – In just one week in Zimbabwe, nearly 100 individuals have fallen ill with typhoid and one person has died. These numbers represent the latest wave in an outbreak that began in October 2016, that has killed at least ten people and infected more than 1,800 others


Antibiotic Resistance

  • Pattern of antimicrobial drug resistance of Salmonella Typhi and Paratyphi A in a Teaching Hospital in Islamabad – The Journal of the Pakistan Medical Association
  • Antimicrobial susceptibility profile, treatment outcome and serotype distribution of clinical isolates of Salmonella enterica subspecies enterica: a 2-year study from Kerala, South India – Infection and Drug Resistance

Complications and Case Studies


  • The epidemiology of childhood Salmonella infections in Alberta, Canada – Foodbourne Pathogens and Disease
  • Characterization of Salmonella Gallinarum from an outbreak in Raigarh, Chhattisgarh – Vet World
  • Treatment response in enteric fever in an era of increasing antimicrobial resistance: an individual patient data analysis of 2,092 participants enrolled into four randomised controlled trials in Nepal – Clinical Infectious Diseases
  • An appraisal of the clinical features of paediatric enteric fever including a systematic review and meta-analysis of the age stratified disease occurence – Clinical Infectious Diseases
  • Epidemiological characteristics and clinical treatment outcome of typhoid fever in Ningbo China, 2005-2014, PFGE results revealing great proportion of common transmission sources – Japanese Journal of Infectious Diseases
  • Epidemiological, clinical, and therapeutic features of typhoid intestinal perforation in a rural environment of Burkina Faso – Medecine et Sante Tropicales


  • Importance of Salmonella Typhi-responsive CD8+ T cell immunity in a human typhoid fever challenge model – Frontiers in Immunology


  • Development of a glycoconjugate vaccine to prevent invasive Salmonella Typhimurium infections in sub-Saharan Africa – PLoS Neglected Tropical Disease
  • High-avidity IgA protects the intestine by enchaining growing bacteria – Nature
  • Mucosal IgA and IFN-γ+ CD8 T cell immunity are important in the efficacy of live Salmonella enteria serovar Choleraesuis vaccines – Scientific Reports


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