Take on Typhoid October Newsletter

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In this issue:

Reaching zero-dose children in Nepal

While planning for their national typhoid conjugate vaccine (TCV) campaign in 2022, Nepal seized the opportunity to reach zero-dose children – those younger than 2 years old who have not received any routine vaccinations – or who are under-immunized. In addition to vaccinating more than 7 million children with TCV, trained healthcare workers used vaccination cards to identify children who had previously missed routine vaccinations. At the time of TCV administration, healthcare workers recorded incomplete vaccinations on the card for each child and provided guidance to caregivers, advising them to visit the nearest health facility to access missed vaccines. Intentional outreach and capturing lessons learned through the introduction of TCV provide a roadmap to identify zero-dose and under-immunized children to ensure all children receive life-saving vaccines.

Typhoid community gathers at ASTMH

Scientists, researchers, clinicians, and students recently gathered to discuss the latest scientific advances in tropical medicine, hygiene, and global health at the American Society of Tropical Medicine and Hygiene (ASTMH) annual meeting. This year’s conference included some of the latest data on typhoid and TCV. We congratulate Dr. Matthew Laurens who was awarded the Bailey K. Ashford Medal for distinguished work in tropical medicine at the conference.

The Coalition against Typhoid hosted a symposium titled, “Strategies for prevention and control of typhoid and cholera outbreaks,” bringing together global health and infectious disease experts to showcase progress toward the development of typhoid diagnostics, specifically in outbreak settings. In addition, the Typhoid Vaccine Acceleration Consortium (TyVAC) hosted a symposium titled, “Generating data on typhoid conjugate vaccine to save lives – clinical studies to country introduction,” which presented updated data from on-going TCV trials in Malawi and Nepal, shared lessons from country introductions in Malawi and Nepal, and discussed the importance of data to policymakers. Read more about efforts to Take on Typhoid here.

Niger surgeons Take on Typhoid

In July, surgeons and medical professionals from Niger convened with local and international typhoid experts, academicians, and representatives from the Minister of Health for the first National Typhoid Conference in Niamey, Niger. Typhoid is a public health crisis in Niger, but like many other countries with significant typhoid, there is limited capacity to confirm a diagnosis using blood cultures tested in a laboratory. Coupled with the lack of access to care, particularly in rural areas, surgeons see an alarmingly high number of typhoid intestinal perforation (TIP), a late complication of typhoid. TCV and improvements in water, sanitation, and hygiene (WASH) remain the best tools to control typhoid and decrease its detrimental impacts.

TyVAC project director honored with Founder’s Day award

Dr. Kathleen Neuzil has led TyVAC since its inception in 2017. A globally recognized vaccinologist with deep expertise in epidemiology, international clinical trials, and vaccine policy, Dr. Neuzil was awarded the 2023 University of Maryland, Baltimore, Researcher of the Year Founders Week Award. This award recognizes Dr. Neuzil’s dedication to vaccine development and equitable distribution, including TCV.

Learn more from Dr. Neuzil about why WASH matters in enteric disease – to include typhoid – prevention and control.

Don’t Miss Out! Register for the International Conference on Typhoid and Invasive Salmonelloses by Nov 13!

The registration deadline for the 13th International Conference on Typhoid and Invasive Salmonelloses has been extended to Nov 13. This event promises to be an enriching and informative experience, with a focus on the latest research and innovations in the fight against typhoid and iNTS. Register now!

Scientific publications

Environmental sampling for typhoidal Salmonellas in household and surface waters in Nepal identifies potential transmission pathways

Assessment of vaccine herd protection in a cluster-randomised trial of Vi conjugate vaccine against typhoid fever: results of further analysis

Risk factors for persistent infection of non-Typhoidal Salmonella in poultry farms, North Central Nigeria

Underestimated economic and social burdens of non-Typhoidal Salmonella infections: The one health perspective from Nigeria

An integrated nationwide genomics study reveals transmission modes of typhoid fever in China

Pan drug-resistant Salmonella serovar Typhi septicaemia in a child: a case report

Early transcriptional responses to human enteric fever challenge

Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

Novel heptaplex PCR-based diagnostics for enteric fever caused by Typhoidal Salmonella serovars and its applicability in clinical blood culture

Assessing the global risk of typhoid outbreaks caused by extensively drug resistant Salmonella Typhi

Visit our publications page for more recent research

Maintaining the momentum to Take on Typhoid: ASTMH Annual Meeting

Nepal’s typhoid conjugate vaccine campaign: a catalyst to reach zero-dose children

Why water, sanitation, and hygiene matter in the fight against typhoid: reflections from leading typhoid researcher and relentless TCV champion Dr. Kathleen Neuzil

New method for needle-free TCV

Surgeons across Niger take on typhoid: National Typhoid Conference

TCV is highly immunogenic in Burkinabe children 30-35 months post-vaccination

Previous posts available on the blog