Knowledge Exchange Newsletter, September 2017

A Note from the CaT Director: CaT joins forces with TyVAC to ‘Take on Typhoid’

Dear Coalition Member,

The Coalition against Typhoid (CaT) is joining forces with the Typhoid Vaccine Acceleration Consortium (TyVAC) to take on typhoid. Together, we will advocate for the use of new typhoid conjugate vaccines and other critical interventions to reduce the burden and impact of typhoid.

As we partner to #TakeOnTyphoid, there are exciting changes coming to CaT, including a new joint website (launching next week) and our newsletter. This edition is the last CaT newsletter in the current format. In November, we will launch a new bi-monthly newsletter with TyVAC as your comprehensive source for typhoid news and research.

In addition to our partnership with TyVAC, CaT will continue its current activities to prevent typhoid, including the International Conference on Typhoid and Other Invasive Salmonelloses. Plans are underway for the next conference in 2019. Stay tuned for more information on the conference and our joint activities with TyVAC.

Thank you for your engagement and support,

Denise Garrett, MD, MSc
Vice President, Typhoid Programs
Director, Coalition against Typhoid (CaT) Secretariat

From the Blog

  • New Study Sheds Light on Typhoid Burden in Rural Nepal – In Nepal, where more than 80 percent of the population is rural, a new study has investigated typhoid outside of major cities. The research, conducted at Dhulikhel Hospital, one of CaT’s partners in the Surveillance of Enteric Fever in Asia Project, is among the first to look into the burden of typhoid in peri-urban and rural Nepalese populations

Typhoid Watch



  • Modifiable risk factors for typhoid intestinal perforations during a large outbreak of typhoidfever, Kampala Uganda, 2015 – BMC Infectious Diseases

Case Reports


  • Non-typhoidal Salmonella in Calabria, Italy: a laboratory and patient-based survey – BMJ Open



  • The Typhi colonization factor (Tcf) is encoded by multiple non-typhoidal Salmonella serovars but exhibits a varying expression profile and interchanging contribution to intestinal colonization – Virulence
  • Vaccination with Salmonella Typhi recombinant outer membrane protein 28 induces humoral but non-protective immune response in rabbit – Vet World
  • Review of current typhoid fever vaccines, cross-protection against paratyphoid fever, and the European guidelines – Expert review of vaccines
  • Use of a novel antigen expressing system to study the Salmonella enterica serovar Typhi protein recognition by T cells – PLoS Neglected Tropical Diseases
  • Risk activities and pre-travel health seeking practices of notified cases of imported infectious diseases in Australia – Journal of Travel Medicine


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