Non-typhoidal salmonella: invasive, lethal, and on the loose


John H Amuasi, Jürgen May


In The Lancet Infectious Diseases, the GBD 2017 Non-Typhoidal Salmonella Invasive Disease Collaborators estimate the global burden of invasive non-typhoidal salmonella disease using Bayesian meta-regression tools. The results show a high but decreasing number of cases since 2005 with a continuously high case fatality rate, consistent with previous estimates. These findings show that serotypes of Salmonella enterica subspecies that cause invasive non-typhoidal salmonella disease are “low-incidence, high-consequence” pathogens. The unique potentiation of mortality from invasive non-typhoidal salmonella disease through HIV infection, malnutrition, and malaria, has further prompted investigation into the burden of this infectious disease in recent times to inform measures for mitigation.

Click here to read the article, published in The Lancet Infectious Diseases.