Comparative Effectiveness Study of Chloramphenicol and Ceftriaxone in the Treatment of Typhoid Fever in Children Admitted to Putri Hijau Kesdam I/Bb Hospital Medan


Eva Sartika Dasopang, Fenny Hasanah, Teddy Kurniawan Bakri, Muktia Isma


Background: Typhoid fever is a disease caused by Salmonella typhi bacteria, especially attacking the digestive tract. Chloramphenicol is the main drug of choice for the treatment of typhoid fever. But along with the advancement of the medical field, other medicines were developed. Ceftriaxone is an effective drug for the treatment of typhoid fever in the short term. But the price of ceftriaxone is more expensive.

Aim: The aim of this study was comparative effectiveness study of Chloramphenicol and Ceftriaxone in the treatment of typhoid fever in children admitted to Putri Hijau Kesdam I/BB Hospital Medan.

Methods: This study was conducted cross-sectionally about the treatment of typhoid fever in children who were hospitalized at TK II PutriHijau Hospital Kesdam I/BB Medan. the patient used cloramfenikol antibiotics in 13 patients and used ceftriaxone in 17 patients. Patient age ranges from 0-19 years. Antibiotic analysis is the best effectiveness using the ACER method.

Results: He results of the patient characteristics show that the children of patients who suffer from typhoid fever, the highest age is 12-16 years (50%), by gender male 60% and female 40%. Patients hospitalized using chloramfenicol averaged 6.53 days (7 days) while ceftriaxon averaged 4.17 days. The average number of direct medical costs in pediatric patients suffering from typhoid fever using cloramfenikol was 3,212,776/patient while ceftriaxon 1,967,045/patient. Cost effectiveness analysis using ACER method obtained results for cloramenicenicol at 492.002/day and ceftriaxon 471,713/day.

Concluson: Ceftriaxone has a better treatment effectiveness compared to chloramphenicol in typhoid fever patients in children.

Click here to read the article, published in the Macedonian Journal of Medical Sciences.