Salmonellosis is characterized by gastroenteritis and enteric fever in humans and affects various organs, particularly in endemic regions and in immunocompromised patients. Here, we report on a 45-year-old male patient with multifocal osteomyelitis, pneumonia and colonic ulcers caused by Salmonella typhi infection. The patient was admitted to our outpatient department with dysuria, fever and hip pain and had been treated with prednisolone and methotrexate for pemphigus vulgaris for two months. After Salmonella typhi was isolated in the urine culture, the patient was hospitalized and treated according to the antibiogram. However, despite antibiotherapy, the patient’s ongoing complaints suggested an existing resistance problem or a rare or atypical involvement of Salmonella spp. As immunosuppressive agents were not used in high doses or for prolonged periods, this disease course and severity were not expected. For an infectious process with an atypical course or multiorgan involvement, particularly in endemic regions and immunocompromised patients, salmonellosis should be considered in the differential diagnosis.
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