Typhoid Fever among Hospitalized Febrile Children in Siem Reap, Cambodia


Lalith P. M. Wijedoru, Varun Kumar, Ngoun Chanpheaktra, Kheng Chheng, Henk L. Smits, Rob Pastoor, Tran Vu Thieu Nga, Stephen Baker, Vanaporn Wuthiekanun5, Sharon J. Peacock, Hor Putchhat, and Christopher M. Parry


Typhoid fever was confirmed by positive blood culture in 5 (3.7%) of 134 febrile children hospitalized in Cambodia. Typhoid was suspected in an additional 25 (18.7 %) blood culture-negative children based on: a positive immunoglobulin M lateral flow assay (IgMFA) (16); a positive polymerase chain reaction (PCR) for Salmonella typhi (2); or clinical assessment (7). The specificity of the IgMFA and PCR assays requires further study.


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