AUTHORS
Ahmad Antar, George Karam, Maurice Kfoury, Nadim El- Majzoub
ABSTRACT
Sickle cell disease (SCD) is a genetic disorder characterized by a marked heterogeneity in clinical
and hematologic severity, with musculoskeletal system manifestations being a major cause of
morbidity and disability. The increased susceptibility of SCD patients to infections, including osteomyelitis, has long been recognized with several mechanisms postulated including
impaired splenic function, defects in complement activation, genetic factors, deficiencies in
micronutrients and the presence of infarcted ornecrotic bone. Salmonella is the most common
cause of osteomyelitis in SCD, followed by Staphylococcus aureus and Gram‐negative enteric
bacilli, this prevalence could be related to the fact that intravascular sickling of the bowel leads
to patchy ischemic infarction. Here, we present a 50‐year‐old female patient with sickle cell anemia who developed parietal osteomyelitis with abscess formation and involvement of the dura due to Salmonella typhi, who was treated successfully by surgery followed by antibiotics.
Click here to view the article, published in the Turkist Journal of Haemotology.
