Detection of a Novel gyrB Mutation Associated With Fluoroquinolone-Nonsusceptible Salmonella enterica serovar Typhimurium Isolated From a Bloodstream Infection in Ghana


Hassan M. Al-Emran, Anke Heisig, Denise Dekker, Yaw Adu-Sarkodie, Ligia Maria Cruz Espinoza, Ursula Panzner, Vera von Kalckreuth, Florian Marks, Se Eun Park, Nimako Sarpong, Jürgen May and Peter Heisig


A multidrug-resistant Salmonella enterica serovar Typhimurium with reduced susceptibility to ciprofloxacin was isolated from the blood of a hospitalized child in Ghana. DNA sequencing identified a novel gyrB mutation at codon 466 (Glu466Asp). An increase in fluoroquinolone susceptibility after the introduction of a wild-type gyrB+ allele demonstrated that the gyrB466 mutation had a direct effect on fluoroquinolone susceptibility.


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