The emergence and outbreak of multidrug-resistant typhoid fever in China

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The emergence and outbreak of multidrug-resistant typhoid fever in China

by Alice Lee June 23, 2016

Authors

Meiyin Yan, Xinlan Li, Qiaohong Liao, Fang Li, Jing Zhang, and Biao Kan

Abstract

Typhoid fever remains a severe public health problem in developing countries. The emergence of resistant typhoid, particularly multidrug-resistant typhoid infections, highlights the necessity of monitoring the resistance characteristics of this invasive pathogen. In this study, we report a typhoid fever outbreak caused by multidrug-resistant Salmonella enterica serovar Typhi strains with an ACSSxtT pattern. Resistance genes conferring these phenotypes were harbored by a large conjugative plasmid, which increases the threat ofSalmonella Typhi and thus requires close surveillance for dissemination of strains containing such genes.

 

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