RpoE promotes invasion and intracellular survival by regulating SPI-1 and SPI-2 in Salmonella enterica serovar Typhi

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RpoE promotes invasion and intracellular survival by regulating SPI-1 and SPI-2 in Salmonella enterica serovar Typhi

by Alice Lee August 5, 2016

AUTHORS

Zhang H., et al

ABSTRACT

Aim

To demonstrate the role of RpoE during the later stage of hyperosmotic stress in Salmonella.

Materials and Methods

Expressions of SPI-1 and SPI-2 under hyperosmotic stress for 120 min were investigated by a microarray, and the invasion and intracellular survival of wild-type and ΔrpoE strains were compared. The global differential expression of bacterial proteins between the wild-type and ΔrpoE strains was examined after 120 min of hyperosmotic stress.

Results

SPI-1 and SPI-2 were repressed, and the invasion and intracellular survival were defected in the ΔrpoE strain. Thirteen bacterial-associated proteins and 11 secreted proteins differed significantly between the wild-type and ΔrpoE strains.

Conclusion

RpoE may promote invasion and intracellular survival by regulating the expression of SPI-1 and SPI-2.

Click here to view the article, published in Future Microbiology.

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