Líneas de Acción 7: Abogar y Comunicación

Mobilize and strengthen global, regional, and national advocacy, communication, and information dissemination on the prevention of enteric fever and the use of typhoid vaccines

The Coalition against Typhoid is dedicated to providing a voice for communities affected by typhoid fever and advocating for the use of typhoid vaccines in populations at risk.

Why is Typhoid an orphan vaccine?

  • In upper income countries, typhoid vaccines are intended for travelers and military personnel, and are not used routinely in children
  • In lower and middle income countries, risk of infection is not universal. Typhoid is concentrated in the poorest, most disenfranchised communities
  • As a result of poor diagnostics and the nonspecific clinical presentation, the burden of disease is under appreciated
  • Existing ViPS and Ty21a vaccines are not effective in the youngest children and only provide a moderate duration of protection
  • Typhoid fever control is addressed by the WHO and other organizations as an outbreak-prone communicable disease, rather than a vaccine-preventable disease within the context of EPI
  • Rather than using existing vaccines, global EPI stakeholders prefer to wait for the next generation of conjugate vaccines

What are the downstream effects?

  • The use of existing ViPS and Ty21a vaccines has not been actively prioritized, creating a lack of incentive for for manufacturers to persue WHO prequalification and become eligible for GAVI financing
  • High-burden communities remain at risk for typhoid fever
  • 21 million people are stricken with typhoid fever every year, resulting in at least 200,000 deaths
  • Typhoid infections can cause adverse pregnancy outcomes, impair physical and cognitive development, impact school attendance and performance and limits productivity in the workforce.
  • Direct and indirect costs of the disease including hospital visits, treatment and lost wages during illness total more than US$100 per infection, placing additional strain on the economies of developing countries, where most families live on less than US$1 per day.