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Emerging enteric fever due to switching biotype of Salmonella (paratyphi A) in Eastern Odisha

by Alice Lee March 15, 2017
AUTHORS Mahapatra A, Patro S, Choudhury S, Padhee A, Das R ABSTRACT BACKGROUND: Typhoid fever is classically caused by Salmonella enterica serotype typhi.Recently the frequency of isolation of S. paratyphi A (SPA) has been increased in comparison to S. typhi in Indian scenario. AIM: To observe the rate of isolation and antimicrobial susceptibility pattern of SPA from suspected enteric fever [...] readmore

Whole-Genome Shotgun Sequencing of Cephalosporin-Resistant Salmonella enterica Serovar Typhi

by Alice Lee March 15, 2017
AUTHORS Rodrigues C, Kapil A, Sharma A, Devanga Ragupathi NK, Inbanathan FY, Veeraraghavan B, Kang G ABSTRACT Typhoid is one of the leading causes of mortality in developing countries. Here, we report the draft genome sequences of four Salmonella enterica serovar Typhi strains isolated from bloodstream infections in a tertiary care hospital. The sequence data indicate genomes of ~4.5 Mb for [...] readmore

The need to strengthen laboratory capacity in Uganda

by Joy Kusiima March 10, 2017
The need to strengthen laboratory capacity in Uganda
This is a guest blog from Dr. Joy Kusiima. Dr. Kusiima is a Fellow with Uganda Public Health Fellowship Programme, Ministry of Health. While travelling to conduct a health needs assessment in Uganda’s countryside, I began to feel unwell and visited the nearest health center. The health worker drew blood and tested for malaria and typhoid – two common infections in Uganda that have [...] readmore

The burden of typhoid fever in low- and middle-income countries: A meta-regression approach

by Alice Lee March 8, 2017
AUTHORS Antillón M, Warren JL, Crawford FW, Weinberger DM, Kürüm E, Pak GD, Marks F, Pitzer VE ABSTRACT BACKGROUND: Upcoming vaccination efforts against typhoid fever require an assessment of the baseline burden of disease in countries at risk. There are no typhoid incidence data from most low- and middle-income countries (LMICs), so model-based estimates offer insights for decision-makers in [...] readmore

Vaccination of active component US military personnel against Salmonella Typhi

by Alice Lee March 8, 2017
AUTHORS Porter CK, Sorrell T, Mitra I, Riddle MS ABSTRACT INTRODUCTION: Vaccination against Salmonella Typhi is one of the leading public health interventions reducing the risk of typhoid fever. There are two available licensed vaccines, Vivotif, oral live-attenuated, and Typhim Vi, intramuscular Vi capsular polysaccharide. The US military is a high risk travel population commonly vaccinated [...] readmore

An association between decreasing incidence of invasive non-typhoidal salmonellosis and increased use of antiretroviral therapy, Gauteng Province, South Africa, 2003-2013

by Alice Lee March 8, 2017
AUTHORS Keddy KH, Takuva S, Musekiwa A, Puren AJ, Sooka A, Karstaedt A, Klugman KP, Angulo FJ ABSTRACT BACKGROUND: HIV-infected persons are at increased risk of opportunistic infections, including invasive nontyphoidal Salmonella (iNTS) infections; antiretroviral therapy (ART) reduces this risk. We explored changing iNTS incidence associated with increasing ART availability in South Africa. [...] readmore

Enteric Fevers, Fallen Empires: When Typhoid and Paratyphoid Toppled Civilizations

by Alice Lee March 6, 2017
Enteric Fevers, Fallen Empires: When Typhoid and Paratyphoid Toppled Civilizations
By today’s standards, enteric fever, which includes typhoid and paratyphoid, is easily treatable and preventable – but in the days before antibiotics and vaccines, outbreaks of these diseases were so devastating that they could endanger entire civilizations.  Researchers have known since 2006 that typhoid fever may have been responsible for the great “plague of Athens” in the 5th century [...] readmore

Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study

by Alice Lee March 1, 2017
AUTHORS Dr Florian Marks, PhD, Vera von Kalckreuth, MD, Peter Aaby, DMSc, Prof Yaw Adu-Sarkodie, PhD, Muna Ahmed El Tayeb, MD, Mohammad Ali, PhD, Abraham Aseffa, PhD, Prof Stephen Baker, PhD, Holly M Biggs, MD, Morten Bjerregaard-Andersen, PhD, Robert F Breiman, MD, James I Campbell, FIBMS, Leonard Cosmas, MPH, Prof John A Crump, MD, Ligia Maria Cruz Espinoza, MD, Jessica Fung Deerin, MPH, [...] readmore

Resistance Patterns of Typhoid Fever in Children: A Longitudinal Community-Based Study

by Alice Lee March 1, 2017
AUTHORS Vala S, Shah U, Ahmad SA, Scolnik D, Glatstein M ABSTRACT Salmonella typhi and S. paratyphi are important causes of bacteremia in children, especially those from the developing world. There is a lack of standardized treatment protocols for such patients in the literature, and there are also reports of therapeutic failure related to resistance to commonly used antibiotics. We analyzed [...] readmore

An outbreak of paratyphoid fever in a county of Yunnan province, 2010-2011

by Alice Lee March 1, 2017
AUTHORS Wang SK, Wang ZG, Zhang XH, Yang B, Wu Q, Kan B, Zhou YH, Yang RS, Yan MY ABSTRACT Objective: To identify the source and to comment on control program regarding an outbreak of paratyphoid A fever in a county, through field studies. Methods: Descriptive epidemiological methods were adopted to describe the epidemiological characteristics of the outbreak, which occurred in Yuanjiang [...] readmore
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