Author / Alice Lee

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A Bioprocessed Polysaccharide from Lentinus edodes Mycelia Cultures with Turmeric Protects Chicks from a Lethal Challenge of Salmonella Gallinarum

by Alice Lee February 22, 2017
AUTHORS Han D, Lee HT, Lee JB, Kim Y, Lee SJ, Yoon JW ABSTRACT Our previous studies demonstrated that a bioprocessed polysaccharide (BPP) isolated from Lentinus edodes mushroom mycelia cultures supplemented with black rice bran can protect mice against Salmonella lipopolysaccharide-induced endotoxemia and reduce the mortality from Salmonella Typhimurium infection through upregulated T-helper [...] readmore

Preclinical efficacy and safety of the Ty21a vaccine strain for intravesical immunotherapy of non-muscle-invasive bladder cancer

by Alice Lee February 22, 2017
AUTHORS Domingos-Pereira S, Cesson V, Chevalier MF, Derré L, Jichlinski P, Nardelli-Haefliger D ABSTRACT Intravesical Bacillus-Calmette-Guérin (BCG) immunotherapy can reduce recurrence/progression of non-muscle-invasive bladder cancer (NMIBC), although significant adverse events and treatment failure argue for alternative options. Here, we examined whether another attenuated live vaccine, [...] readmore

Emerging insights into the biology of typhoid toxin

by Alice Lee February 22, 2017
AUTHORS Fowler CC, Chang SJ, Gao X, Geiger T, Stack G, Galán JE ABSTRACT Typhoid toxin is a unique A2B5 exotoxin and an important virulence factor for Salmonella Typhi, the cause of typhoid fever. In the decade since its initial discovery, great strides have been made in deciphering the unusual biological program of this toxin, which is fundamentally different from related toxins in many [...] readmore

Salmonella enterica Serotype Typhi Bacteremia Complicating Pregnancy in the Third Trimester

by Alice Lee February 22, 2017
AUTHORS Guirguis GF, Patel K, Gittens-Williams L, Apuzzio JJ, Martimucci K, Williams SF ABSTRACT Background. Salmonella enterica serotype Typhi (S. Typhi) is an anaerobic gram-negative enteric rod that causes infection when contaminated food or water is ingested and may cause illness in pregnancy. Case. This is a patient who presented at 31 weeks’ gestation with abdominal pain and fever [...] readmore

Differential roles for pathogenicity islands SPI-13 and SPI-8 in the interaction of Salmonella Enteritidis and Salmonella Typhi with murine and human macrophages

by Alice Lee February 22, 2017
AUTHORS Espinoza RA, Silva-Valenzuela CA, Amaya FA, Urrutia ÍM, Contreras I, Santiviago CA ABSTRACT BACKGROUND: Salmonella pathogenicity island (SPI)-13 is conserved in many serovars of S. enterica, including S. Enteritidis, S. Typhimurium and S. Gallinarum. However, it is absent in typhoid serovars such as S. Typhi and Paratyphi A, which carry SPI-8 at the same genomic location. Because the [...] readmore

Knowledge Exchange Newsletter January/February 2017

by Alice Lee February 21, 2017
Knowledge Exchange Newsletter January/February 2017
​​Stories of Typhoid: Asim Meet Asim. In his low-income urban neighborhood in Pakistan, it can seem as if the one thing more widespread than typhoid is misinformation about typhoid. Crucial information on the prevention of the disease through handwashing, drinking clean water or receiving a vaccination is often missing in places where typhoid is endemic, leaving kids like Asim at high risk of [...] readmore

Stories of Typhoid: Asim

by Alice Lee February 16, 2017
Stories of Typhoid: Asim
Meet Asim. In his low-income urban neighborhood in Pakistan, it can seem as if the one thing more widespread than typhoid is misinformation about typhoid. Crucial information on the prevention of the disease through handwashing, drinking clean water or receiving a vaccination is often missing in places where typhoid is endemic, leaving kids like Asim at high risk of suffering unnecessarily [...] readmore

Modeling the Potential for Vaccination to Diminish the Burden of Invasive Non-typhoidal Salmonella Disease in Young Children in Mali, West Africa

by Alice Lee February 15, 2017
AUTHORS Bornstein K, Hungerford L, Hartley D, Sorkin JD, Tapia MD, Sow SO, Onwuchekwa U, Simon R, Tennant SM, Levine MM ABSTRACT BACKGROUND: In sub-Saharan Africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal Salmonella (NTS) to be a major pathogen exhibiting high case fatality (~20%). Where [...] readmore

Salmonella Typhi Lipopolysaccharide O-antigen Modifications Impact on Serum Resistance and Antibody Recognition

by Alice Lee February 15, 2017
AUTHORS Kintz E, Heiss C, Black I, Donohue N, Brown N, Davies MR, Azadi P, Baker S, Kaye PM, van der Woude M ABSTRACT Salmonella Typhi is a human restricted Gram-negative bacterial pathogen, responsible for causing an estimated 27 million cases of typhoid fever annually leading to 217,000 deaths, and current vaccines do not offer full protection. The O-antigen side chain of the [...] readmore

Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study

by Alice Lee February 15, 2017
AUTHORS Marks F, von Kalckreuth V, Aaby P, Adu-Sarkodie Y, El Tayeb MA, Ali M, Aseffa A, Baker S, Biggs HM, Bjerregaard-Andersen M, Breiman RF, Campbell JI, Cosmas L, Crump JA, Espinoza LM, Deerin JF, Dekker DM, Fields BS, Gasmelseed N, Hertz JT, Van Minh Hoang N, Im J, Jaeger A, Jeon HJ, Kabore LP, Keddy KH, Konings F, Krumkamp R, Ley B, Løfberg SV, May J, Meyer CG, Mintz ED, Montgomery JM, [...] readmore
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