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Ensuring resistance doesn’t take hold: The importance of taking on typhoid now

by Kathleen Neuzil June 15, 2017
Ensuring resistance doesn’t take hold: The importance of taking on typhoid now
This blog post was originally published on the Global Health Technologies Coalition’s Breakthroughs Blog. Typhoid may seem like a distant memory in industrialized countries, but for many low- and middle-income countries (LMICs) it continues to cause millions of illnesses and about 150,000 deaths per year in endemic areas and during outbreaks. Spread through contaminated food and water, [...] readmore

Career Opportunity: Postdoctoral Fellow

by Alice Lee June 8, 2017
Career Opportunity: Postdoctoral Fellow
The University of Otago Centre for International Health is hiring for a postdoctoral fellow. This position would be primarily responsible for conducting systematic reviews and meta-analyses of published data, landscape analyses of unpublished ongoing work and data gaps analyses on global typhoid fever epidemiology relevant for typhoid vaccine policy. Apply here by June 30. readmore

Meet Gul Rahim

by Alice Lee May 26, 2017
Meet Gul Rahim
This is Gul Rahim’s story of typhoid, as told to Attaullah Baig of Aga Khan University Hospital on January 7, 2017, and translated into English. The interview was conducted in Urdu and has been edited for clarity and length. I am a 15 -year -old boy from a remote and underprivileged village in District Buner, Khyber Pakhtukhwa of Pakisan. My father is too elderly to be employed and my older [...] readmore

From Evidence to Action: Typhoid Experts Exchange Data, Strategies During Biannual Conference

by Hannah Bassett May 24, 2017
From Evidence to Action: Typhoid Experts Exchange Data, Strategies During Biannual Conference
More than 300 researchers from 45 countries gathered in Kampala, Uganda in early April for the 10th International Conference on Typhoid and Other Invasive Salmonelloses. Hosted by the Sabin Vaccine Institute’s Coalition against Typhoid, the three-day conference – the world’s only such meeting devoted to the diseases – centered on the theme “From Evidence to Action” as attendees reviewed [...] readmore

Performance of TUBEX® TF in the diagnosis of enteric fever in private tertiary care Hospital Peshawar, Pakistan

by Alice Lee May 24, 2017
AUTHORS Khan K, Khalid L, Wahid K, Ali I ABSTRACT OBJECTIVE: To evaluate the performance of TUBEX® TF in diagnosing enteric fever. METHODS: The retrospective study was performed at the Northwest General Hospital and Research Centre, Peshawar, Pakistan, and comprised data of all patients who had blood cultures and TUBEX®TF performed as part of their evaluation from April 2011 to November 2015. [...] readmore

Comparing laboratory surveillance with the notifiable diseases surveillance system in South Africa

by Alice Lee May 24, 2017
AUTHORS Benson FG, Musekiwa A, Blumberg L, Rispel LC ABSTRACT OBJECTIVE: The aim of this study was to compare laboratory surveillance with the notifiable diseases surveillance system (NDSS) in South Africa. METHODS: Data on three tracer notifiable diseases – measles, meningococcal meningitis, and typhoid – were compared to assess data quality, stability, representativeness, [...] readmore

Cost-effectiveness analysis of typhoid conjugate vaccines in five endemic low- and middle-income settings

by Alice Lee May 24, 2017
AUTHORS Antillón M, Bilcke J, Paltiel AD, Pitzer VE ABSTRACT BACKGROUND: Typhoid fever remains endemic in low- and middle-income countries. Programmatic use of existing vaccines is limited, but upcoming typhoid conjugate vaccines (TCVs) could warrant wider use. We evaluated the cost-effectiveness of five TCV delivery strategies in three urban areas (Delhi and Kolkata, India and Nairobi, [...] readmore

Committee Head for Coalition against Typhoid Wins Prestigious Award

by Alice Lee May 22, 2017
Committee Head for Coalition against Typhoid Wins Prestigious Award
The Coalition against Typhoid is proud to announce that Dr. Samir Saha, the chair of our steering committee, is the distinguished recipient of the 2017 Award for Research in Clinical Microbiology. This award, given by the American Society of Microbiology, recognizes a clinical microbiologist for outstanding lifetime achievements that have led to or formed the foundation for important [...] readmore

A case report of anaphylaxis to Typhoid Vaccine Live Oral Ty21a (Vivotif)

by Alice Lee May 17, 2017
AUTHORS Haas NL, Haas MRC, Gregory C ABSTRACT Typhoid Vaccine Live Oral Ty21a (Vivotif) is typically well tolerated, and adverse events are infrequent and mild. To the best of the authors’ knowledge, only one prior anaphylactic reaction has previously been reported. We present a case of anaphylaxis related to Vivotif, in which a 66-year-old male with no medical comorbidities developed [...] readmore

A novel approach for construction of an inactivated typhoid vaccine candidate that effectively augments both humoral and cellular immune responses

by Alice Lee May 17, 2017
AUTHORS Won G, Kim B, Lee JH ABSTRACT Salmonella enterica serovar Typhi ghost was constructed as a vaccine candidate against typhoid fever. An asd+ plasmid pJHL187 harboring a ghost cassette comprised of PhiX 174 E lysis gene stringently controlled under the convergent promotor components and was transformed into the asd gene-deleted mutant S. Typhi Ty21a strain (STG). Twenty female BALB/c [...] readmore
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