Author / Alice Lee

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A case report of anaphylaxis to Typhoid Vaccine Live Oral Ty21a (Vivotif)

by Alice Lee May 17, 2017
AUTHORS Haas NL, Haas MRC, Gregory C ABSTRACT Typhoid Vaccine Live Oral Ty21a (Vivotif) is typically well tolerated, and adverse events are infrequent and mild. To the best of the authors’ knowledge, only one prior anaphylactic reaction has previously been reported. We present a case of anaphylaxis related to Vivotif, in which a 66-year-old male with no medical comorbidities developed [...] readmore

A novel approach for construction of an inactivated typhoid vaccine candidate that effectively augments both humoral and cellular immune responses

by Alice Lee May 17, 2017
AUTHORS Won G, Kim B, Lee JH ABSTRACT Salmonella enterica serovar Typhi ghost was constructed as a vaccine candidate against typhoid fever. An asd+ plasmid pJHL187 harboring a ghost cassette comprised of PhiX 174 E lysis gene stringently controlled under the convergent promotor components and was transformed into the asd gene-deleted mutant S. Typhi Ty21a strain (STG). Twenty female BALB/c [...] readmore

Correlates of protection for enteric vaccines

by Alice Lee May 17, 2017
AUTHORS Holmgren J, Parashar UD, Plotkin S, Louis J, Ng SP, Desauziers E, Picot V, Saadatian-Elahi M ABSTRACT An immunological Correlate of Protection (CoP) is an immune response that is statistically interrelated with protection. Identification of CoPs for enteric vaccines would help design studies to improve vaccine performance of licensed vaccines in low income settings, and would [...] readmore

New Findings for Typhoid Fever in Africa

by Alice Lee May 17, 2017
New Findings for Typhoid Fever in Africa
For years, little was known of the typhoid burden in Africa, even though outbreaks of multi-drug resistant typhoid were becoming increasingly common. This lack of information spurred the Bill and Melinda Gates Foundation to fund the Typhoid Fever Surveillance in Africa Program (TSAP) through the International Vaccine Institute, a first-of-its-kind study established to shed light on true [...] readmore

Genotypic and phenotypic characterization of multidrug resistant Salmonella Typhimurium and Salmonella Kentucky strains recovered from chicken carcasses

by Alice Lee May 10, 2017
AUTHORS Rizwana Tasmin, Nur A. Hasan, Christopher J. Grim, Ar’Quette Grant, Seon Young Choi, M. Samiul Alam, Rebecca Bell, Christopher Cavanaugh, Kannan V. Balan, Uma S. Babu, Salina Parveen ABSTRACT Salmonella Typhimurium is the leading cause of human non-typhoidal gastroenteritis in the US. S. Kentucky is one the most commonly recovered serovars from commercially processed poultry [...] readmore

Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa

by Alice Lee May 9, 2017
AUTHORS Elin Näsström, Christopher M Parry, Nga Tran Vu Thieu, Rapeephan R Maude, Hanna K de Jong, Masako Fukushima, Olena Rzhepishevska, Florian Marks, Ursula Panzner, Justin Im, Hyonjin Jeon, Seeun Park, Zabeen Chaudhury, Aniruddha Ghose, Rasheda Samad, Tan Trinh Van, Anders Johansson, Arjen M Dondorp, Guy E Thwaites, Abul Faiz, Henrik Antti, Stephen Baker ABSTRACT Salmonella Typhi is the [...] readmore

The impact of migration and antimicrobial resistance on the transmission dynamics of typhoid fever in Kathmandu, Nepal: A mathematical modelling study

by Alice Lee May 5, 2017
AUTHORS Saad NJ, Bowles CC, Grenfell BT, Basnyat B, Arjyal A, Dongol S, Karkey A, Baker S, Pitzer VE ABSTRACT BACKGROUND: A substantial proportion of the global burden of typhoid fever occurs in South Asia. Kathmandu, Nepal experienced a substantial increase in the number of typhoid fever cases (caused by Salmonella Typhi) between 2000 and 2003, which subsequently declined but to a higher [...] readmore

Salmonella Typhi Associated Endogenous Endophthalmitis: A Case Report and a Review of Literature

by Alice Lee April 28, 2017
AUTHORS Dadia SD, Modi RR, Shirwadkar S, Potdar NA, Shinde CA, Nair AG ABSTRACT AIM: To report a rare case of Salmonella typhi associated endogenous endophthalmitis in an immunocompetent male and to review the available literature. METHODS: Retrospective chart review. RESULTS: A 28-year-old immunocompetent male presented with a 3-day-old history of pain, redness and diminished vision in his [...] readmore

Career Opportunity: Postdoctoral Fellow

by Alice Lee April 28, 2017
Career Opportunity: Postdoctoral Fellow
The University of Otago Centre for International Health is hiring for a postdoctoral fellow. This position would be primarily responsible for conducting systematic reviews and meta-analyses of published data, landscape analyses of unpublished ongoing work and data gaps analyses on global typhoid fever epidemiology relevant for typhoid vaccine policy. Apply here by April 30. readmore

Differential Effects of Inflammatory and Psychosocial Stress on Mood, Hypothalamic-Pituitary-Adrenal Axis, and Inflammation in Remitted Depression

by Alice Lee April 27, 2017
AUTHORS Niemegeers P, De Boer P, Dumont GJH, Van Den Eede F, Fransen E, Claes SJ, Morrens M, Sabbe BGC ABSTRACT BACKGROUND/AIMS: Major depressive disorder (MDD) is highly recurrent. This may be due to increased stress sensitivity after remission. Both inflammatory and psychosocial stressors are implicated in the pathogenesis of MDD, but the additive or differential effect is unclear. METHODS: [...] readmore