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Salmonella Typhi genomics: envisaging the future of typhoid eradication

by Alice Lee August 23, 2017
AUTHORS Yap KP, Thong KL ABSTRACT Next-generation whole-genome sequencing has revolutionised the study of infectious diseases in recent years. The availability of genome sequences and its understanding have transformed the field of molecular microbiology, epidemiology, infection treatments and vaccine developments. We review the key findings of the publicly accessible genomes of Salmonella [...] readmore

In silico identification and characterization of stress and virulence associated repeats in Salmonella

by Alice Lee August 23, 2017
AUTHORS Das G, Das S, Dutta S, Ghosh I ABSTRACT So much genomic similarities yet causing different diseases, is like a paradox in Salmonella biology. Repeat is one of the probes that can explain such differences. Here, a comparative genomics approach is followed to identify and characterize repeats that might play role in adaptation and pathogenesis. Repeats are non-randomly distributed in [...] readmore

Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol

by Alice Lee August 23, 2017
AUTHORS Alvarez MI, Glover LC, Luo P, Wang L, Theusch E, Oehlers SH, Walton EM, Tram TTB, Kuang YL, Rotter JI, McClean CM, Chinh NT, Medina MW, Tobin DM, Dunstan SJ, Ko DC ABSTRACT Risk, severity, and outcome of infection depend on the interplay of pathogen virulence and host susceptibility. Systematic identification of genetic susceptibility to infection is being undertaken through [...] readmore

Knowledge Exchange Newsletter June 2017

by Alice Lee June 30, 2017
Knowledge Exchange Newsletter June 2017
Featured In “Ensuring resistance doesn’t take hold: The importance of taking on typhoid now,” Dr. Kathleen Neuzil, director of the Center for Vaccine Development, urges us all to #TakeOnTyphoid before available antibiotics are no longer able to treat typhoid A PLOS Global Health blog post, “When water doesn’t flow…”, takes a hard look at the impact the lack [...] readmore

Ensuring resistance doesn’t take hold: The importance of taking on typhoid now

by Kathleen Neuzil June 15, 2017
Ensuring resistance doesn’t take hold: The importance of taking on typhoid now
This blog post was originally published on the Global Health Technologies Coalition’s Breakthroughs Blog. Typhoid may seem like a distant memory in industrialized countries, but for many low- and middle-income countries (LMICs) it continues to cause millions of illnesses and about 150,000 deaths per year in endemic areas and during outbreaks. Spread through contaminated food and water, [...] readmore

From Evidence to Action: Typhoid Experts Exchange Data, Strategies During Biannual Conference

by Hannah Bassett May 24, 2017
From Evidence to Action: Typhoid Experts Exchange Data, Strategies During Biannual Conference
More than 300 researchers from 45 countries gathered in Kampala, Uganda in early April for the 10th International Conference on Typhoid and Other Invasive Salmonelloses. Hosted by the Sabin Vaccine Institute’s Coalition against Typhoid, the three-day conference – the world’s only such meeting devoted to the diseases – centered on the theme “From Evidence to Action” as attendees reviewed [...] readmore

Committee Head for Coalition against Typhoid Wins Prestigious Award

by Alice Lee May 22, 2017
Committee Head for Coalition against Typhoid Wins Prestigious Award
The Coalition against Typhoid is proud to announce that Dr. Samir Saha, the chair of our steering committee, is the distinguished recipient of the 2017 Award for Research in Clinical Microbiology. This award, given by the American Society of Microbiology, recognizes a clinical microbiologist for outstanding lifetime achievements that have led to or formed the foundation for important [...] readmore

New Findings for Typhoid Fever in Africa

by Alice Lee May 17, 2017
New Findings for Typhoid Fever in Africa
For years, little was known of the typhoid burden in Africa, even though outbreaks of multi-drug resistant typhoid were becoming increasingly common. This lack of information spurred the Bill and Melinda Gates Foundation to fund the Typhoid Fever Surveillance in Africa Program (TSAP) through the International Vaccine Institute, a first-of-its-kind study established to shed light on true [...] readmore

Knowledge Exchange Newsletter April 2017

by Alice Lee April 26, 2017
Knowledge Exchange Newsletter April 2017
A Successful Conference Thank you to all those who presented or attended the 10th International Conference on Typhoid and Other Invasive Salmonelloses in Kampala, Uganda! The three day conference was well-received, convening a diverse audience of 300 individuals from 45 countries. For those who missed it, or would like to share the experience with colleagues, we have the following resources [...] readmore

Typhoid Carried from Overseas Brings Global Threat to New Zealand

by Alice Lee April 25, 2017
Typhoid Carried from Overseas Brings Global Threat to New Zealand
Overseas travelers can sometimes bring back unwanted souvenirs — with tragic consequences. A localized outbreak of typhoid in Auckland, New Zealand has taken the life of one patient and affected 20 others. Public health authorities believe that a traveler to a typhoid-endemic country may have unknowingly contracted the disease and carried it back into the country. Typhoid, a bacterial [...] readmore
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