An assessment of liver function test in typhoid fever in children

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An assessment of liver function test in typhoid fever in children

by Alice Lee July 1, 2016

AUTHORS

Jain H., Arya S., Iskram S., Mandloi R., & Xess V.

ABSTRACT

Background

Liver involvement is known in typhoid and may be in the form of hepatomegaly, jaundice, biochemical and histopathological changes. Isolated hepatomegaly is of no clinical significance, but its occurrence with jaundice though rare indicates liver involvement as a result of generalized toxemia or invasion by salmonella. Significant liver damage may have occurred without obvious clinical signs or abnormal laboratory tests.

Aim of study

Assessment of liver functionin typhoid fever in children diagnosed by widal agglutination test by biochemical test.

Setting

Fifty-four cases of typhoid fever less than 16 years admitted inPaediatric Department MY Hospital, MGM Medical College Indore, comprised the clinical material for the study.

Design

Cross sectional study.

Method

54 children with enteric fever were taken after making clinical diagnosis, confirmed by Widaltest and LFT was performed to assess liver involvement.

Result

Hepatomegaly was seen in 19 [35%] cases and tender hepatomegaly was seen in 2 cases of the study group. S.G.O.T was raised in 27 [50%] cases and S.G.P.T was raised in 25 [46%] cases out of total 54 cases. Most of the cases with raised S.G.O.T and S.G.P.T presented in the 2nd week of fever. Serum bilirubin was raised in only 2 cases.

Statistical Analysis

Kruskalwallis test was applied.

Conclusion

Out of 54 cases S.G.O.T was raised in 27 cases and S.G.P.T in 25 cases. Most cases with raised S.G.O.T and S.G.P.T presented in the s 2nd week of fever. Serum bilirubin was raised in only 2 cases

Click here to view the article, published in Tropical Medicine & International Health.

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