Agenda

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Tuesday, March 26   |   Wednesday, March 27   |   Thursday, March 28

TUESDAY, MARCH 26

Welcome Remarks
Amy Finan, Sabin Vaccine Institute
Welcome Remarks and Housekeeping Items
Denise Garrett, Sabin Vaccine Institute
Opening Keynote
Kathleen Neuzil, University of Maryland School of Medicine
Where Are We With Diagnosing Typhoid Fever?
Stephen Baker, University of Oxford
Low-Cost PCR-based Microbial Quantification Methods for Water Quality Control in the Developing World
Michael Hoffmann, California Institute of Technology
Integrating WASH/Hygiene Behaviour Change Interventions into Routine Immunization Programme to Maximise Benefits: WaterAid’s Experiences from Pilot to Scale
Om Prasad Gautam, WaterAid
Typhoid Conjugate Vaccine Development: The Last Mile?
Sushant Sahastrabuddhe, International Vaccine Institute
Grand BallroomCarry That Weight: Burden of Disease
SESSION MODERATED BY:
Dennis Chao, Institute for Disease Modeling & Robert F. Breiman, Emory University
Truc BachWe Can Work It Out: Vaccine Development
SESSION MODERATED BY:
Krishna Ella, Bharat Biotech International Limited &
Laura Martin, GSK Vaccines Institute for Global Health
Tenacious Endemic Typhoid Fever in Samoa: Is Short-Cycle (Chronic Carriers) or Long-Cycle (Water-Borne) Transmission Mainly Maintaining
Endemicity?
Myron (Mike) Levine, University of Maryland School of Medicine
Age-Associated Heterogeneity of Ty21a-Induced T Cell Responses to HLA-E Restricted Salmonella Typhi Antigen resentation
Marcelo B. Sztein, University of Maryland, Baltimore
Illness Severity and Outcomes among Enteric Fever Cases – Data from the Surveillance for Enteric Fever in Asia Project (SEAP)
Caitlin Barkume, Sabin Vaccine Institute
Preclinical Development of a Trivalent Typhoid-Nontyphoidal Salmonella Glycoconjugate Vaccine for sub-Saharan Africa
Scott Baliban, University of Maryland, Baltimore
The Burden of Culture-Confirmed Enteric Fever in an Urban Slum – An Ongoing Community-Based Longitudinal Cohort in Delhi, India (Tier 1 SEFI site)
Bireshwar Sinha, Society for Applied Studies
Development of a MAPS-Based Typhoid and Paratyphoid A Vaccine
Richard (Rick) Malley, Boston Children’s Hospital
Spatial and Temporal Patterns of Typhoid and Paratyphoid Outbreaks: A Worldwide Systematic Review, 1990-2016
Vittal Mogasale, International Vaccine Institute
The Non-Specific Immunological Impact of Human Oral Vaccination with Live-Attenuated Salmonella Typhi
Shaun Pennington, Liverpool School of Tropical Medicine
Mortality Attributed to Ileal Perforations: Prospective Data from a Multi-Centers Enteric Fever Surveillance Project in Pakistan
Saqib Qazi, Aga Khan University Hospital
T Cell Mediated Immunity Elicited in Volunteers Following Immunization with the Live Oral Salmonella Paratyphi A Attenuated Vaccine Strain CVD 1902
Rezwanul Wahid, University of Maryland School of Medicine
The Global Burden of Nontyphoidal Salmonella Invasive Disease: A Systematic Analysis for the Global Burden of Disease Study 2017
Andrea Parisi, The Australian National University
The Immunogenicity and Safety of ZyVac-TCV, a Typhoid Conjugate Vaccine in Healthy Indian Subjects: Results of First Comparative Clinical Trial
Pavankumar Daultani, Cadila Healthcare Limited
Approach for Harmonization and Quality Control of Environmental Surveillance Methods for Typhoid
John Scott Meschke, University of Washington
Environmental Surveillance for Typhoid in Kibera, an Informal Settlement in Nairobi, Kenya
Jennifer Verani & Jennifer Murphy, Centers for Disease Control and Prevention
Development and Application of Pilot Salmonella Typhi in Environmental Surveillance Program in Kolkata, India
Christine L. Moe, Emory University
Environmental Sampling as a Tool for Identification of High Typhoid Risk Settings
Jason Andrews, Stanford University
Environmental Surveillance for Salmonella and AMR Genes in Tamil Nadu, India
Sidhartha Giri, Christian Medical College, Vellore
Country Decision Making on Typhoid Conjugate Vaccine (TCV) Introduction: Potential Role of Environmental Surveillance
Adwoa Bentsi-Enchill, World Health Organization
Grand BallroomI Should Have Known Better: Antimicrobial Resistance SESSION MODERATED BY:
Chris Parry, University of Liverpool & Hubert Endtz Fondation Mérieux
Truc BachHere, There, Everywhere: Environmental Surveillance, Disease Modeling, and Geo-Spatial Analysis
SESSION MODERATED BY:
Nicholas (Nick) Feasey, Liverpool School of Tropical Medicine & Supriya Kumar, Bill & Melinda Gates foundation
Antimicrobial Non-Susceptibility among Salmonella Typhi and Paratyphi A Isolates – Preliminary Results from SEAP Project
Muhammad Tahir Yousafzai, Aga Khan University
Clinical and Genomic Data to Understand Transmission Patterns of Typhoid Fever and
Inform Targeted Environmental Sampling in
Blantyre, Malawi
Jillian Gauld, Institute for Disease Modeling & Lancaster University
Trends in Resistance to Fluoroquinolones and ESBLs among Salmonella Typhi Isolates from Patients at Outpatient Clinics in Nairobi, 2012-2016
Susan Kavai, Kenya Medical Research Institute
Optimisation of Culture and Molecular-Based Methods for Detection of Salmonella
Typhi from Environmental Reservoirs under Laboratory Conditions

Jonathan Rigby, Liverpool School of Tropical Medicine
Incidence and Antimicrobial Resistance Profile of Salmonella Bacteremia Among Children in sub-Saharan Africa: RTS,S/AS01 Salmonella Ancillary Study
Calman MacLennan, University of Oxford
Environmental Surveillance for Targeting Typhoid Conjugate Vaccines: Drivers of Cost-Efficiency in sub-National Programs
Brittany Hagedorn, Institute for Disease Modeling
Salmonella Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance
Arif Mohammad Tanmoy, Erasmus University Medical Center
Typhoid Environmental Surveillance Sampling Strategies and Adaptive Sampling Site Allocation Method: A Simulation Study for Wards 58 & 59, Kolkata
Yuke Wang, Emory University
Molecular Mechanisms of Antimicrobial Resistance and Phylogenetic Relationship of Salmonella
enterica from Febrile Patients in Yangon, Myanmar

Tin Ohn Myat, University of Medicine 1
A Bayesian Approach for Estimating Typhoid Fever Incidence from Passive Surveillance Data
Maile Phillips, Yale School of Public Health
Predicting the Impact of Typhoid Conjugate Vaccines on Antimicrobial Resistance
Virginia (Ginny) Pitzer, Yale School of Public Health
Geo-Spatial Reporting of Ceftriaxone Resistant Salmonella Typhi Outbreak Investigation in Hyderabad and Spread to Karachi
Abdul Momin Kazi, Aga Khan University

WEDNESDAY, MARCH 27 Back to Top

Burden of Enteric Fever in Africa and Asia from Three Urban Centres: A Multicentre, Prospective Epidemiological Study with over 600,000 Person-Years of Observation
James Meiring, University of Oxford
Serial Serological Surveillance for Typhoid in Healthy Community Controls in Nepal, and in Fever Cases and Their Families
Merryn Voysey, University of Oxford
Evaluation of Population-Based Serological Surveillance for the Identification of Typhoid Chronic Carriers Using and Anti-Vi IgG ELISA
Farhana Khanam, icddr,b
Interim Analysis of Safety of Typhoid Conjugate Vaccine across Africa and Asia TyVAC
Melita Gordon, University of Liverpool
Interim Analysis of Immunogenicity of Typhoid Conjugate Vaccine in Africa and Asia TyVAC
Dikshya Pant, Patan Academy of Health Sciences
Efficacy of Typhoid Conjugate Vaccine in Nepal: A Participant-Observer-Blind Phase III Randomized Controlled Trial
Mila Shakya, Oxford University Clinical Research Unit, Nepal
Grand BallroomGot to Get You into My Life: Introduction of TyphoidConjugate Vaccines
SESSION MODERATED BY:
Ken Simiyu, University of Maryland School of Medicine & Salman Muhammad, National Institute of Health, Pakistan
Truc BachFixing a Hole: iNTS
SESSION MODERATED BY:
Ellis Owusu-Dabo, Kwame Nkrumah University of Science and Technology & Sam Kariuki , Kenya Medical Research Institute
Safety of Typhoid Conjugate Vaccine in Bangladeshi Children: Preliminary Results from a
Double-Blind Cluster-Randomised Controlled Trial
Firdausi Qadri, icddr,b
The Phylogeography and Incidence of Multi-Drug Resistant Invasive Nontyphoidal Salmonella in sub-Saharan Africa
Se Eun Park, International Vaccine Institute
Implementation and Coverage of the First Public Sector Introduction of Typhoid Conjugate Vaccine, Navi Mumbai, India
Kashmira Date, Centers for Disease Control and Prevention
Transmission of Invasive Nontyphoidal
Salmonella: Supporting Evidence for Humanto-Human Transmission from Household Samples in Burkina Faso

Annelies Post, Radboudumc Nijmegen & Institute of Tropical Medicine Antwerp
Evaluation of Vaccine Safety during the First Public Sector Introduction of Typhoid Conjugate Vaccine (TCV), Navi Mumbai, India, 2018
Ashley Tate, CDC Foundation
Fifteen Years of Surveillance for Invasive Salmonellosis in Bamako, Mali: 2002 to 2017
William Still, University of Maryland, Baltimore
Adverse Events following Immunization with Typbar TCV and Measles Vaccine: Mass Immunization against Typhoid Fever and Measles at KGH Hospital Karachi
Anayat Baig, Aga Khan University
Characterising the Cellular and Humoral Immune Response to Invasive Nontyphoidal Salmonella
(iNTS) Disease in West African Populations
Sean Elias, University of Oxford
Door to Door Campaign of Typbar TCV: Strategies to Reduce Refusal and Increase Coverage
Sultan Karim, Aga Khan University
Characterization of Invasive Salmonellosis in Hospitalized Children with Acute Febrile
Illness: Uganda, 2016-2017

Alison Winstead, Centers for Disease Control and Prevention
Safety and Tolerability of a Novel Typhoid Conjugate Vaccine in African Infants and Children
Nginache Nampota, Blantyre Malaria Project
What Have We Learned from the 10,000 Salmonella Genomes Project about the Worldwide Epidemiology, Transmission and Virulence of iNTS?
Blanca Perez Sepulveda, University of Liverpool
Gavi Typhoid Program: History of Decision-Making, Current Support and Early Lessons Learned
Adam Soble, Gavi, the Vaccine Alliance
On The Essentials of Using Data for Decision Making and Advocacy
N.A. Gonah, Zimbabwe National Immunisation Technical Advisory Group
Advocating to Save Lives: Learnings From Vaccine Introduction Programs
Anjali Nayyar, Global Health Strategies
Advocating for New Vaccine Introduction in the Mekong Region: Lessons Learnt From Laos, Cambodia,
Myanmar, and Vietnam
Huong Vu Minh, PATH
Advocacy for Vaccine in LMICs: Focusing on Typhoid
Samir Saha, Child Health Research Foundation & Dhaka Shishu Hospital
Grand BallroomAcross the Universe: Enteric Fever Surveillance
SESSION MODERATED BY:
John Clemens, icddr,b & Megan Carey, Bill & Melinda Gates Foundation
Truc BachTell Me Why: Immunology
SESSION MODERATED BY:
Kim Mulholland, Murdoch Children’s Research Institute & Richelle Charles, MassachusettsGeneral Hospital
S. Typhi and iNTS Disease in Africa – Implications for Vaccination Programs: Results of the Severe Typhoid in Africa Program and Future Trial Plans
Florian Marks, International Vaccine Institute & University of Cambridge
Long Term Persistence of Antibodies to Typbar-TCV Vaccination
Krishna Mohan, Bharat Biotech International
Age-Stratified Incidence of Enteric Fever and Vaccination Implications in Bangladesh, Nepal and Pakistan: Results of the Surveillance for Enteric Fever in Asia Project
Denise Garrett, Sabin Vaccine Institute
Host Gene Expression Signatures for Enteric Fever Diagnosis
Christoph Blohmke, University of Oxford
Decline in Typhoid Fever Incidence in Kibera, an Urban Informal Settlement in Nairobi, Kenya
Eric D. Ng’eno, Washington State University
Measurement of Antibody Dependent Neutrophil Phagocytosis and the Respiratory Burst against Salmonella Typhi
Mari Johnson, Oxford Vaccine Group
Incidence of Typhoid and Paratyphoid Fevers among Adolescents and Adults in Yangon, Myanmar
Win Thandar Oo, University of Otago
On the Early Cellular Immune Response during Salmonella Typhi Infection
Marije Verheul, University of Oxford
Validity of Reported Antibiotic Use among Suspected Enteric Fever Cases in Nepal, Bangladesh and Pakistan
Krista Vaidya, Dhulikhel Hospital
Anti-Vi IgG and IgA Persistence following Immunisation with Vi Conjugate and Polysaccharide Vaccines
Elizabeth Jones, Oxford Vaccine Group
PathogenWatch: Fast and Interactive Genomic Surveillance of Salmonella Typhi, an Example from a Retrospective Study in the Philippines
Silvia Argimón, Centre for Genomic Pathogen Surveillance
Stem Cell-Derived Gut Organoids and Macrophages as an In Vitro Model for Studying the Interactions of S. Typhi and S. Paratyphi A with the Human Host Emily Lees, University of Cambridge & Wellcome Trust Sanger Institute

THURSDAY, MARCH 28 Back to Top

Surveillance for Enteric Fever in Asia Project (SEAP) II: Health Facility Cost of Illness Preliminary Results Nelly Mejia Gonzalez, Centers for Disease Control and Prevention
Severe Typhoid Fever Surveillance in Africa Programme (SETA): Patient Cost of Illness Preliminary Results
Enusa Ramani, International Vaccine Institute
Forecasting Demand for the Typhoid Conjugate Vaccine in Low- and Middle-Income Countries
Clint Pecenka, PATH
Costs of Typhoid Conjugate Vaccine Delivery Strategies in Navi Mumbai, India
Dayoung Song, International Vaccine Institute
Cost-Effectiveness of Typhoid Vaccination Strategies: Evidence Gaps and Recommended Methods
Virginia (Ginny) Pitzer, Yale School of Public Health
Grand BallroomDon’t Let Me Down:From Data to Policy
SESSION MODERATED BY:
Mathuram Santosham, Johns Hopkins University & Tony Marfin, PATH
Truc BachThe Long and Winding Road: Genomics
SESSION MODERATED BY:
Firdausi Qadri, icddr,b & Gordon F. Dougan, University of Cambridge
Utilization of Healthcare Services for Enteric Fever under National Health Insurance Program in Selected Districts of Nepal
Palpasa Kansakar, Health Insurance Board, Nepal
Assessment of Population Structure and Antimicrobial Resistance Pattern of Salmonella Typhi Isolates using Whole Genome Sequencing Data in Bangladesh
Sadia Isfat Ara Rahman, icddr,b
Healthcare-Seeking Patterns for Individuals with Suspected Enteric Fever
Alexander Yu, Stanford University
Integration of Transcriptomic and Genomic Data Reveals Important Aspects of the Early Host Response to Salmonella Typhi Infection
Amber Barton, University of Oxford
Typhoid Fever in the U.S. Pediatric Population and the Potential Benefits of New Vaccines
Grace Appiah, Centers for Disease Control and Prevention
Phenotypic and Genotypic Analysis of Ciprofloxacin Treatment on Phylogenetically-Related Invasive Salmonella Typhimurium
Sushmita Sridhar, Wellcome Sanger Institute
A Multidisciplinary Approach to Increase Awareness and Strengthen the Case for the Introduction of a Vaccine against Invasive Nontyphoidal Salmonella
Gianluca Breghi, Fondazione Achille Sclavo
Comparative Genome and Transcriptome Analysis of Antibody Resistant and Susceptible Invasive African Salmonella Typhimurium Isolates
Edna Ondari, Swiss Tropical and Public Health Institute
Comparison of Cost of Illness of Extensively Drug-Resistant (XDR) vs. Non-XDR Typhoid Fever in Pakistan: Policy Implications for Typhoid Vaccine Ashar Malik, Aga Khan University DNA-Gyrase/Topoisomerase-IV Mutations and Antibiotic Susceptibility Patterns of Salmonella Paratyphi A
Mohammad Saiful Islam Sajib, Child Health Research Foundation
Epidemiology of Typhoid and Paratyphoid: Implications for Vaccine Policy
Senjuti Saha, Child Health Research Foundation
The Role of Genomics in Typhoid Control: Sentinel Traveler Surveillance, In-Host Evolution, and Transmission Dynamics
Zoe Dyson, University of Cambridge, University of Melbourne & Monash University
Magical Mystery Tour: The Late Breakers
SESSION MODERATED BY:
Farah Qamar, Aga Khan University & Myron (Mike) Levine, University of Maryland School of Medicine
Assessment of Humoral and Cellular Responses to Vi Polysaccharide Vaccine as a Booster after Vi Conjugate Prime
Thomas Bentley, Oxford Vaccine Group
Extensively Drug Resistant Typhoid Fever in Karachi, Sindh: An Analysis of Lab Based Surveillance Data, 2018
Ishfaque Hussain Memon, FELTP
Emergence of Azithromycin Resistance in Typhoidal Salmonella in Dhaka, Bangladesh
Senjuti Saha, Child Health Research Foundation & Stanford University
Salmonella Non-Typhi Stool Excretion after Bloodstream Infection in DRC: Proportion and Genetic Similarity between Paired Blood and Stool Isolates
Marie-France Phoba, National Institute for Biomedical Research
Community-Based Incidence of Typhoid in India
Jacob John, Christian Medical College, Vellore
A Contagious City: 120 Years of Typhoid Control and Eradication in Oxford (1840-1960)
Claas Krichhelle, University of Oxford
Data Gaps as Obstacles to Elimination
Jeffrey (Jeff) Stanaway, Institute of Health Metrics and Evaluation
Considerations for Typhoid Elimination
John A. Crump, University of Otago
A Timeline for Typhoid Elimination
Stephen Luby, Stanford University
The Role of Vaccination Towards Elimination
Phionah Atuhebwe, World Health Organization Regional Office for Africa
Closing Keynote Address
Anita Zaidi, Bill & Melinda Gates Foundation
Meeting Adjournment
Denise Garrett, Sabin Vaccine Institute