Stories of Typhoid: Meet Yadav
Mithila Jariwala / Sabin Vaccine Institute
Meet Yadav. A 27-year-old lab assistant in Gurgaon, India, Yadav is remarkably conscientious about avoiding diseases transmitted through contaminated food and water. He cooks at home to avoid eating food bought on the street, where the risk of transmission is much higher. He drinks filtered water, and washes his hands with soap on a regular basis. Yet Yadav’s precautions could not totally overcome the risks of life in his village, which is plagued by water and sewage problems.
So despite his precautions, Yadav fell ill with typhoid. The classic symptoms hit him with full force; a high fever, constant nausea, bouts of vomiting and worst of all, body aches and fatigue. “I couldn’t sleep at night,” said Yadav. “It was very hard on me.” Read more about his story.
Save the Date
The 10th International Conference on Typhoid and Other Invasive Salmonelloses will be held in Kampala, Uganda, from April 4-6, 2017. Abstract and symposium submissions are open now and close October 28. Head to our website for submission guidelines and more conference information. Help us promote the conference, encourage diverse participation from across the world, and let your network know where you’ll be in April with our Social Media Toolkit!
- November 14 from 4:00 PM – 5:45 PM: Bridging the Gap Towards Defining the Burden of Typhoid in Sub-Saharan Africa and Southeast Asia. Symposium #45.
- November 15 from 4:00 PM – 6:00 PM: Typhoid, Paratyphoid and Invasive Non-Typhoidal Salmonella: A Time for Action. Side event in room 205 at the Hilton Atlanta. Contact us for more information.
- Fiji – Typhoid outbreak confirmed in several areas of the country after Tropical Cyclone Winston.
- India – Panic grips a Bijnor village after typhoid and dengue kill nine in ten days and sicken 75. In Khammam District, hospitals have treated at least 6,716 patients for typhoid. Eight children are dead in Tiruvallur as a typhoid outbreak is made worse by “quacks” providing false medicines. Villagers living near the Wariana dump report at least one case of typhoid in every household. Two children dead and 90 villagers sickened by a “mysterious fever” in Shirar. St George’s College in Mussoorie closed just before exams because of typhoid and viral fever cases.
- Kenya – Residents in Kiogoro ward are reporting cases of typhoid after their water supply was cut off.
- Nepal – Hundreds of typhoid cases in Ramechhap due to water contaminated with fecal coliform.
- Sudan – Outbreaks of disease including typhoid in the Sortony North Darfur refugee camp threaten to pose a major humanitarian disaster.
- Uganda – Several patients report being treated for typhoid in Lira.
The Dirt on Water
- Asia, Africa, and Latin America – a report by the UN Environment Programme warns that a worrying rise in pathogen pollution in surface waters could put up to 323 million people at risk of infection.
- India – Illegal access to water pipelines from unauthorized colonies on the outskirts of Gurgaon has contaminated the water supply so that 15 percent of the homes in Gurgaon are now receiving water that is not safe for drinking.
- Zimbabwe – The government has entered into a public-private partnership to improve the ineffective waste management system, which has exposed urban residents to outbreaks of disease. This decision comes after the capital, Harare, is officially declared typhoid-free after a spring outbreak.
- Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a – PLOS Neglected Tropical Diseases
- Extended Spectrum Beta Lactamase producing Cephalosporin resistant Salmonella Typhi, reported from Rawalpindi, Pakistan – Journal of Pakistan Medical Association
- Third-generation cephalosporin-resistant non-typhoidal Salmonella isolated from human feces in Japan – Japanese Journal of Infectious Diseases
- Antimicrobial susceptibility pattern and sequence analysis of DNA gyrase and DNA topoisomerase IV in Salmonella enterica serovars Typhi and Paratyphi A isolates with decreased susceptibility to ciprofloxacin – Transactions of the Royal Society of Tropical Medicine and Hygiene
Diagnostics and Treatments
- Bacteriophage tailspike protein based assay to monitor phase variable glucosylations in Salmonella O-antigens – BMC Microbiology
- A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever – Scientific Reports
- Health at the Sub-catchment Scale: Typhoid and Its Environmental Determinants in Central Division, Fiji – Ecohealth
- Enteric Fever in a Tertiary Paediatric Hospital: A Retrospective Six-Year Review – Annals of the Academy of Medicine, Singapore
- The contribution of travellers visiting friends and relatives to notified infectious diseases in Australia: state-based enhanced surveillance – Epidemiology and Infection
- Typhoid Salmonellae: Use of Multi-Locus Sequence Typing to Determine Population Structure – PLoS One
- Geographical and temporal trends in imported infections from the tropics requiring inpatient care at the Hospital for Tropical Diseases, London – a 15 year study – Transactions of the Royal Society of Tropical Medicine and Hygiene
Genomics and Host Susceptibility
- Elevated Values of C-Reactive Protein Induced by Imported Infectious Diseases: A Controlled Cross-Sectional Study of 11,079 Diseased German Travelers Returning from the Tropics and Subtropics – The American Journal of Tropical Medicine and Hygiene
- Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings – Nature Genetics